The Permeation of Benzodiazepines through Synthetic Membranes
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概要
- 論文の詳細を見る
The permeation of chlordiazepoxide, diazepam, oxazepam, lorazepam, nitrazepam, and nimetazepam through a dimethylpolysiloxane membrane and that of chlordiazepoxide, oxazepam, and nitrazepam through an ethylene-vinyl acetate copolymer membrane were investigated using a newly designed permeation cell. Large permeability values of diazepam and nimetazepam were attributed to their large partition coefficients. Large lag time values of chlordiazepoxide, oxazepam, and nitrazepam through the silicone membrane were rationalized by adsorption of these drugs on silica filler within the silicone membrane. Thus permeation data of these drugs can be interpreted on the basis of their physical properties.
- 公益社団法人日本薬学会の論文
- 1979-03-25
著者
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中野 眞汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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荒川 佳子
Department of Anesthesiology, Faculty of Medicine, Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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荒川 佳子
Department Of Anesthesiology Faculty Of Medicine Hokkaido University
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郡 修徳
Faculty of Pharmaceutical Sciences, Hokkaido University
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荒川 佳子
Faculty of Pharmaceutical Sciences, Hokkaido University
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郡 修徳
Faculty Of Pharmaceutical Sciences Hokkaido University
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