Adsorption and Prevention of Gastrointestinal Absorption of Nalidixic Acid by Activated Carbon Beads

概要

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An activated carbon preparation suitable for oral administration as a gastrointestinal adsorbent was prepared by drying spherical beads in which 8% activated carbon powder was dispersed in 4% agar. The preparation, activated carbon beads containing about 67% activated carbon powder in agar matrices, consists of palatable fine granules with good flow properties and is free from many of the handling problems associated with activated carbon powder. In an adsorption test in vitro using nalidixic acid, no reduction of the adsorbing capacity of activated carbon powder was observed as a consequence its incorporation into agar beads. Administration of 10 g of the beads 20 min after an oral dose of 500 mg of nalidixic acid effectively reduced intestinal absorption of the drug by about 53% (p<0.02), based on the 24 h cumulative excretion of the drug in urine. These results indicate that the preparation is a promising candidate as a gastrointestinal adsorbent for the early treatment of possible intoxication by acidic drugs.
公益社団法人日本薬学会の論文
1986-10-25