A Comparison of Bioavailability of Free Bases and Hydrochloride Salts of Chlortetracycline, Demethylchlortetracycline, and Methacycline
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概要
- 論文の詳細を見る
Gastrointestinal absorption of the free base and the hydrochloride of chlortetracycline (CTC) was studied in rats and human subjects. Following oral administration, the free base produced higher CTC levels in the body fluids than the hydrochloride. The difference between the bioavailability of the free base and that of the hydrochloride was due to the difference in the solubility characteristics at the gastric pH. Similar investigations were carried out with demethylchlortetracycline (DMCT) and methacycline (MOTC). The results indicated that plasma level after oral administration of MOTC base to rats was slightly higher than that of the hydrochloride and plasma levels of DMCT base and the hydrochloride were essentially identical. In the study comparing the cumulative amounts of MOTC base and the hydrochloride after oral administration to human subjects, the free base gave greater cumulative amounts than the hydrochloride in two of the three subjects.
- 公益社団法人日本薬学会の論文
- 1975-09-25
著者
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中野 眞汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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宮崎 正三
東日本学園大学薬学部
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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