Pluronic F-127 Gels as a Vehicle for Topical Administration of Anticancer Agents
スポンサーリンク
概要
- 論文の詳細を見る
Pluronic F-127 (a polyoxyethylene-polyoxypropylene surface-active block copolymer) was evaluated as a vehicle substance for topical administration of anticancer agents. 5-Fluorouracil and adriamycin were used in this evaluation. The effects of the concentration of Pluronic F-127,temperature, and the drug concentration on the release were studied by means of an in vitro release method using a cellulose membrane. With increasing concentration of Pluronic F-127 in the vehicle a corresponding decrease in the apparent release rate of the anticancer agents occurred. The apparent release rate increased with increasing temperature from 30 to 44℃. Increase in drug concentration increased the drug release rate. The Pluronic F-127 gels appeared to have good potential for use in topical drug delivery systems since they exhibit reverse thermal gelation behavior and have good drug release characteristics and low toxicity.
- 1984-10-25
著者
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滝野 吉雄
School of Pharmaceutical Sciences, University of Shizuoka
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宮崎 正三
北海道医療大学薬学部
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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横内 千鶴子
Faculty of Pharmaceutical Science, Higashi-Nippon Gakuen University
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横内 千鶴子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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滝野 吉雄
School Of Pharmaceutical Sciences University Of Shizuoka
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滝野 吉雄
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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