Studies on Absorption, Distribution, Excretion and Metabolism of Ginseng Saponins. VIII. Isotope Labeling of Ginsenoside Rb_2
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概要
- 論文の詳細を見る
To clarify the pharmacokinetics of absorption, distribution and excretion of ginsenoside Rb_2 (Rb_2), one of the major saponins of the root of Panax ginseng, following oral administration to rats, a tritium (^3H) labeling of Rb_2 was examined. The C-12 position of Rb_2 was labeled with ^3H-sodium borohydride (^3H-NaBH_4) and 12-^3H Rb_2 and 12-^3H-epi Rb_2 was synthesized. This method of specific position labeling of Rb_2 may be applicable to other ginsenosides. In the near future, the pharmacokinetics of Rb_2 in rats may be clarified with ^3H labeled Rb_2.
- 社団法人日本薬学会の論文
- 1992-09-25
著者
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谷澤 久之
静岡県立大学薬学部
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滝野 吉雄
静岡県立大学薬学部
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谷澤 久之
School of Pharmaceutical Sciences, University of Shizuoka
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滝野 吉雄
School of Pharmaceutical Sciences, University of Shizuoka
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谷沢 久之
静岡県立大学 薬
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平田 崇
School Of Pharmaceutical Sciences University Of Shizuoka
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宮瀬 敏男
School Of Pharmaceutical Sciences University Of Shizuoka
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狩倉 正実
School of Pharmaceutical Sciences, University of Shizuoka
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Miyake T
School Of Pharmaceutical Sciences University Of Shizuoka
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狩倉 正実
School Of Pharmaceutical Sciences University Of Shizuoka
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滝野 吉雄
School Of Pharmaceutical Sciences University Of Shizuoka
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