Studies on Absorption, Distribution, Excretion and Metabolism of Ginseng Saponins. V. : The Decomposition Products of Ginsenoside Rb_2 in the Large Intestine of Rats

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The decomposition of ginsenoside Rb_2 (Rb_2) in the rat large intestine after oral administration was investigated in detail. A part of Rb_2 was decomposed and six decomposition products (I-VI) were observed on thin-layer chromatogram. Among them, five products (I-V) were isolated, and identification of these compounds was done by carbon-13 nuclear magnetic resonance (^<13>C-NMR).On the basis of ^<13>C-NMR analysis, these compounds were identified as ginsenoside Rd (I), 3-O-β-D-glucopyranosyl-20-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-proto-panaxadiol (II), ginsenoside F_2 (III), 20-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (IV), and compound K (V), respectively.
社団法人日本薬学会の論文
1990-10-25