Studies on the Absorption, Distribution, Excretion and Metabolism of Ginseng Saponins. II. The Absorption, Distribution and Excretion of Ginsenoside Rg_1 in the Rat

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The pharmacokinetic charactor of ginsenoside Rg_1,one of the main saponins of ginseng (Panax ginseng C.A. MEYER), was investigated in rats by using thin-layer chromatography (TLC) and a dual-wavelength TLC scanner. Ginsenoside Rg_1 was absorbed rapidly from the upper parts of the digestive tract (accounting for 1.9-20.0% of the dose of Rg_1 administered orally). The serum level of ginsenoside Rg_1 reached its peak at 30 min, and the maximum levels of ginsenoside Rg_1 in tissues were attained within 1.5 h. However, ginsenoside Rg_1 was not found in the brain. Ginsenoside Rg_1 was excreted into rat urine and bile in a 2 : 5 ratio. It was also proved that ginsenoside Rg_1 was not significantly metabolized in the liver. However, the decomposition and/or metabolism of ginsenoside Rg_1 in rat stomach and large intestine were confirmed.
公益社団法人日本薬学会の論文
1983-01-25