α-L-Iduronidaseの研究-3-実験的慢性障害肝におけるα-L-Iduronidase活性の変動

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The changes of activities of α-L-Iduronidase and other various glycosidases were examined in the course of rat liver fibrosis induced with carbon tetrachloride.<BR>4 weeks after initiation of carbon tetrachloride treatment, the hepatic fibrosis was not observed but the activity of α-L-Iduronidase was increased to 94% above controls. All of other glycosidase activities examined in the present study exhibited also an increasing tendency.<BR>In 6, 8 or 12 weeks of treatment by carbon tetrachloride, α-L-Iduronidase activity showed the further increase with the development of fibrosis. However, other glycosidase activities were not increased and some showed the slight decreasing tendency as compared with the group treated by carbon tetrachloride for 4 weeks but were higher than the normal values.
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