Methotrexate 処理ラットの生体反応に対する小柴胡湯及び Mecobalamin の改善作用.血液流体特性を中心として

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It was found that the subcutaneous treatment with 0.6 mg/kg of methotrexate (MTX) twice a week for 7 weeks in rat led to the increases in blood viscosity-adjusted hematocrit and serum lipidperoxide level and a decrease in the expansibility of erythrocyte during the course of hypotonic hemolysis. The effect of sho-saiko-to, one of the useful kampo prescriptions used in traditional Chinese system of medicine, on biological responses in MTX-treated rats was examined mainly from the biorheological view points. The combined use of sho-saiko-to and MTX inhibited the blood flow properties affected by MTX treatment. It was also found that the administration of sho-saiko-to inhibited the decrease of body weight and the increase of liver lipidperoxide induced by MTX treatment. The MTX-induced increase of liver lipidperoxide level was also restored by the administration of mecobalamin which showed no effect on the blood viscosity and body weight affected by MTX treatment.
社団法人日本薬学会の論文
1987-03-25