Effects of Flavonoids and Related Compounds from Mulberry Tree on Arachidonate Metabolism in Rat Platelet Homogenates
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概要
- 論文の詳細を見る
The effects of various flavonoids and related compounds isolated from the root bark of mulberry tree on rat platelet lipoxygenase and cyclooxygenase products formed from [1-^<14>C] arachidonic acid were studied. Morusin was found to inhibit the formations of 12-hydroxy-, 8,10-heptadecatrienoic acid (HHT) and thromboxane B_2 (cyclooxygenase products) more strongly than the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product). Oxydihydromorusin and kuwanon C were also found to inhibit the formation of thromboxane B_2 more strongly than the formations of HHT and 12-HETE. Mulberrofuran A inhibited the formations of HHT and thromboxane B_2,but it increased the formation of 12-HETE. Albanol B and mulberrofuran F did not affect arachidonate metabolism in rat platelet homogenates.
- 公益社団法人日本薬学会の論文
- 1986-03-25
著者
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深井 俊夫
東邦大・薬
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野村 太郎
Faculty of Pharmaceutical Sciences, Toho University
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木村 善行
愛媛大学大学院医学系研究科統合医科学講座薬理生化学分野
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野村 太郎
Faculty Of Pharmaceutical Sciences Toho University
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野村 太郎
東邦大 薬
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有地 滋
The Research Institute of Oriental Medicine, Kinki University
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有地 滋
The Research Institute Of Oriental Medicine Kinki University
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有地 滋
近畿大学東洋医学研究所
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奥田 拓道
愛媛大学
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奥田 拓道
熊本県立大学環境共生学部環境共生学科食健康環境学科
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奥田 拓道
2nd Department of Medical Biochemistry, School of Medicine, Ehime University
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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木村 善行
2nd Department of Medical Biochemistry, School of Medicine, Ehime University
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深井 俊夫
Faculty of Pharmaceutical Sciences, Toho University
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有地 滋
愛媛大学
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