20 桑根皮のDiels-Alder付加化合物の構造

概要

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From the Chinese crude drug "Sang-Bai-Pi" (Japanese name Sohakuhi), the root barks of Morus sp. (Moraceae), five new flavanone derivatives were isolated and named sanggenon A, B, C, D, and E. Their structures were shown to be V, VI, VII, VIII, and IX, respectively. Intravenous injection of VII and VIII (0.5mg/Kg) produced a significant hypotension in rat. Sanggenon B, C, D, and E are regarded biogenetically as Diels-Alder adducts of chalcone derivatives and a sanggenon A derivative. Two Diels-Alder adducts, mulberrofuran C and kuwanon I, were isolated from the root barks of the cultivated mulberry tree (a variety of Morus alba L.) and their structures were shown to be XI and XII, respectively. Mulberrofuran C (XI) to rabbit (1mg/Kg, i.v.) produced a significant hypotension. The long-range selective ^1H decoupling (LSPD) technique was examined to presume the disposition concerning the location of the phenyl and benzoyl moiety on the cyclohexene ring of the model compounds.
天然有機化合物討論会の論文
1981-09-10