22 Penicillium diversum var aureumの生産する抗腫瘍性代謝産物について

概要

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Three new trihydroxynaphthalenones(PD-2, PD-3 and PD-4) have been isolated from the culture filtrate of P. diversum var. aureum together with three known naphthalenones, sclerone(PD-5), isosclerone(PD-6) and juglone(PD-7), and herqueinone(PD-1), major metabolite of this fungus, has also been isolated from the mycelium. The structure of PD-3 was determined on the basis of its chemical properties and the spectroscopic analyses on PD-3 methylether(Ia) and PD-3 dimethylether(Ic). The ^1H-NMR decoupling experiments on Ia revealed the presence of the partial structures A and B. Finally, the structure of PD-3 was confirmed by the application of the ^<13>C-^1H long range selective proton decoupling experiments on its dimethylether which was obtained from PD-3 by the action of diazomethane. The structures of PD-2 and PD-4 were also determined by comparison of their ^1H-NMR data with those of PD-3, PD-5 and PD-6. PD-2, PD-3 and PD-4 showed cytotoxity against Yoshida sarcoma cells in tissue culture at 20-50mcg/ml respectively.
天然有機化合物討論会の論文
1983-09-15