微生物によるSantonin誘導体の構造変換
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概要
- 論文の詳細を見る
Microbiological transformation of α-santonin analogs with culture broths of Aspergillus ochraceus, Fusarium nivale, and F. solani is described. 4α-Oxide (II) and 4β-oxide (III) were transformed to the corresponding 1,2-dihydro-3β-hydroxy derivatives (VII), (VIII), and IX, respectively). 3α-Acetoxy derivative (V) was hydrolysed to the 3α-hydroxy derivative (X) in a good yield. 3β-Chloro derivative (VI) was stereoselectively transformed to the compound (X) with inversion of the C_3-configuration. Benzoquinone (XV) was reduced to hydroquinone by Asp. ochraceus, while microbiological transformation of compounds XI, XII, XIII, and XIV was not observed.
- 社団法人日本薬学会の論文
- 1978-02-25
著者
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清水 猛
理化学研究所袖岡有機合成化学研究室
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辰野 高司
理化学研究所
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藤本 康雄
The Institute Of Physical And Chemical Research
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辰野 高司
Institute of Physical and Chemical Research
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藤本 康雄
理研
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藤本 康雄
理化学研究所
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石本 富雄
理化学研究所
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清水 猛
理研
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