Studies on the Metabolites of Penicillium diversum var. aureum. II. : Synthesis and Cytotoxic Activity of Trihydroxytetralones
スポンサーリンク
概要
- 論文の詳細を見る
(±)-2,4,5- and 2,4,8-Trihydroxy-1-tetralones (2,9,3,11) were synthesized from juglone, and their cytotoxic activities against Yoshida sarcoma cells were examined. The trihydroxytetralones were more cytotoxic than dihydroxytetralones. While the configuration of the hydroxyl groups in the alicyclic ring scarcely affected the cytotoxicity against Yoshida sarcoma cells, the position of the hydroxyl groups in the aromatic ring seem to be important. The 2,4,8-trihydroxytetralones (3,11) were more cytotoxic than the 2,4,5-trihydroxy derivatives (2,9).
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
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藤本 康雄
The Institute of Physical and Chemical Research (Rikagaku Kenkyusho) Komagome, Tokyo
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藤本 康雄
日本大学薬学部
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藤本 康雄
The Institute Of Physical And Chemical Research
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藤本 康雄
日本大学 薬
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佐藤 美鶴
昭和薬科大学
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佐藤 美鶴
The Institute of Physical and Chemical Research
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