5-Lipoxygenase Inhibitors Isolated from Gardeniae Fructus

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概要

• 論文の詳細を見る

• Five 5-lipoxygenase inhibitors, chlorogenic acid (1), 6''-p-coumaroyl genipin gentiobioside (2), 3,4-di-O-caffeoylquinic acid (3), 3-O-caffeoyl-4-O-sinapoylquinic acid (4) and 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid (5), were isolated from Gardeniae Fructus. The structures of the new compounds (2,4 and 5) were elucidated on the basis of spectral data and chemical evidence. These hydroxycinnamic acid derivatives inhibit 5-lipoxygenase activity, and 3 was the most potent inhibitor. The inhibitory effects were enhanced on methylation of the carboxyl group(s) of 1,3,4 and 5,and the ID<50> values of the methyl esters of 3,4 and 5 were of the order of 10<-8>M.

• 公益社団法人日本薬学会の論文
• 1988-01-25

著者

• 藤本 康雄

  The Institute of Physical and Chemical Research (Rikagaku Kenkyusho) Komagome, Tokyo

• 藤本 康雄

  The Institute Of Physical And Chemical Research

• 藤本 康雄

  College Of Pharmacy Nihon University

• 金子 光

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 西澤 信

  北大・薬

• 金子 光

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 西澤 信

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 出原 留利子

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 腰原 康子

  Tokyo Metropolitan Institute of Gerontology

• Nishizawa M

  Hokkaido Univ. Sapporo Jpn

• 出原 留利子

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 腰原 康子

  都立老人研薬理部

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