28 ガガイモ科Cynanchum属のプレグナン配糖体について
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概要
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On the constituents of Asclepiadaceous plants, a couple of Cynanchum sp. plants were investigated. We wish to report here the structures of the new compounds, atratogenin A(1) from C. atratum, cynajapogenin A(2) from C. japonicum, neocynapanogenin A(13) of the aglycone of neocynapanoside A(14) from C. paniculatum, and boerharigenin A(5) and B(6) from C. boerharifolium. Both atratogenin A(1) and cynajapogenin A(2) contain a 2,3 disubstituted furan ring which may be derived from the C-15 aldehyde and C-20 oxo group formed by oxidative cleavage at C-14,15 bond of hypothetical precursor such like 14β-hydroxy pregnenolone (4) which is isolated from C. paniculatum. The latter compoud(2) lacked C-18 methyl group. Neocynapanogenin A(13), an aglycone of 14, has an exo α,β unsaturated five membered lactone ring in addition to the nine membered lactone like glaucogenins type compound. Both 5 and 6 have the same substitution system in the ring D and defferent in that the former has benzoyloxygenated C-19 methyl. A plausible biogenetical pathway for pregnane type aglycones of the Cynanchum plants is given in the chart 1.
- 天然有機化合物討論会の論文
- 1986-09-09
著者
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中川 喬
津村研
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三橋 博
津村研究所
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林 紘司
北大薬
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
Tsumura Institute For Biology And Chemistry
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林 紘司
Tsumura Central Research Laboratories Tsumura & Co.
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菅間 恒
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
北海道大学薬学部
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金子 光
Faculty of Pharmaceutical Sciences, Hokkaido University
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菅間 恒
北大薬
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張 壮〓
北大薬
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塚本 佐知子
北大薬
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中谷 比奈子
北大薬
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佐々木 啓子
北大薬
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金子 光
北大薬
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塚本 佐知子
Faculty of Pharmaceutical Sciences, Hokkaido University
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金子 光
Faculty Of Pharmaceutical Sciences Hokkaido University
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塚本 佐知子
Faculty Of Pharmaceutical Sciences Hokkaido University
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金子 光
北海道大学 薬
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林 紘司
北海道大学薬学部
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