Syntheis and Protective Effect of 1,3,5-Triazine Derivatives, Leukotriene C^4 Antagonist, on HCl・Ethanol-Induced Gastric Lesions in Rats
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概要
- 論文の詳細を見る
2,4-Diamino-[E]-6-[2-(3-pyridyl)ethenyl]1,3,5-triazine (3a), leukotriene C_4 (LTC_4) antagonist, was found to possess a protective effect of HCl・ethanol-induced gastric lesions. Analogues of 3a were synthesized and evaluated for the effect as well as antagonistic activity against LTC_4-induced contraction. Seven compounds (3a-d, f-h) exhibited a potent protective effect on gastric lesions which was considered to be based on the antagonistic activity against LTC_4. The structure-activity relationships of the derivatives (3a-k) are discussed.
- 社団法人日本薬学会の論文
- 1991-12-25
著者
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佐藤 俊次
(株)ツムラ生物化学研究所
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長谷川 賀洋
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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柳澤 利彦
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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奥井 由佳
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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佐藤 俊次
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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穂坂 邦男
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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陳 正雄
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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三橋 博
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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三橋 博
津村研究所
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
Tsumura Institute For Biology And Chemistry
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三橋 博
(株)ツムラ中央研究所
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奥井 由佳
(株)ツムラ中央研究所
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柳澤 利彦
(株)ツムラ中央研究所
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三橋 博
ツムラ生物・化学研所
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陳 正雄
Research Institute For Biology & Chemistry Tsumura Co. Ltd.
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穂坂 邦男
Research Institute For Biology & Chemistry Tsumura Co. Ltd.
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長谷川 賀洋
Research Institute For Biology & Chemistry Tsumura Co. Ltd.
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