Studies on the Constituents of Asclepiadaceae Plants. LVI. Isolation of New Antitumor-Active Glycosides from Dregea volubilis (L.) BENTH.
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概要
- 論文の詳細を見る
Seven new glycosides were isolated from the stem of Dregea volubilis (L.) BENTH. The structures of dregeosides A_<p1> (1), A_<o1> (2), A_<a1> (3), A_<11> (4), C_<11> (5), K_<a1> (6), and K_<a1> (7) were deduced on the basis of chemical and spectral evidence as drevogenin A 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin A 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin A 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin A 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin C 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drebyssogenin K_2 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, and drebyssogenin K_2 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, respectively. Among them, 1 and 2 were active against Ehrlich carcinoma (solid type), and the latter was also active against melanoma B-16.
- 社団法人日本薬学会の論文
- 1983-11-25
著者
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三橋 博
Faculty of Pharmaceutical Sciences, Hokkaido University
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林 紘司
Faculty of Pharmaceutical Sciences, Hokkaido University
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
Tsumura Institute For Biology And Chemistry
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三橋 博
Faculty Of Pharmaceutical Sciences Hokkaido University
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林 紘司
Tsumura Central Research Laboratories Tsumura & Co.
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吉村 慎一
Faculty Of Pharmaceutical Sciences Hokkaido University
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成田 弘美
Faculty of Pharmaceutical Sciences, Hokkaido University
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成田 弘美
Faculty Of Pharmaceutical Sciences Hokkaido University
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林 紘司
Faculty Of Pharmaceutical Sciences Hokkaido University
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林 紘司
北海道大学薬学部
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