Studies on the Constituents of Asclepiadaceae Plants. XX. Epimerization at C-17 and Optical Rotatory Dispersion Study of C/D cis Pregnan-20-one Derivatives. 2

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概要

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• Alkaline treatment of C/D cis-pregnan-20-one derivatives produced an equilibrium mixture of 17α-and 17β-H-20-keto compounds. The 17β-H-epimers are the more stable form and their rotatry dispersion curves show negative Cotton effects. The 17α-H-20-keto compounds, the less stable form, show positive Cotton effects. The ratios of these two epimers were calculated from the optical rotatory dispersion curves and varied with the influence of neighboring groups.

• 社団法人日本薬学会の論文
• 1966-07-25

著者

• 三橋 博

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 三橋 博

  Research Institute For Biology & Chemistry Tsumura & Co.

• 三橋 博

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 野村 太郎

  Faculty of Pharmaceutical Sciences, Toho University

• 野村 太郎

  Faculty Of Pharmaceutical Sciences Toho University

• 福岡 正道

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 福岡 正道

  National Institute of Hygienic Sciences

• 三橋 博

  (株)ツムラ生物・化学研究所

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