Marine Sterols. XI. Polyhydroxysterols of the Soft Coral Sarcophyton glaucum : Isolation and Synthesis of 5α-Cholestane-1β, 3β, 5,6β-tetrol

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概要

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• (24S)-24-Methylcholest-5-ene-3β, 25-diol (ergost-5-ene-3β, 25-diol, 3), (24S)-24-methyl-5α-cholestane-1β, 3β, 5,6β-tetrol (5α-ergostane-1β, 3β, 5,6β-tetrol, 2a), and a new sterol, 5α-cholestane-1β, 3β, 5,6β-tetrol (1), were isolated from the soft coral Sarcophyton gluacum. The structure of 1 was confirmed by the spectroscopic data and by synthesis starting from ruscogenin. The configurations at C-24 of the known C_<28>-polyhydroxysterols (2-5) were shown to be (S) by proton nuclear magnetic resonance (^1H-NMR) analysis or by correlation to 22,23-dihydrobrassicasterol (16a).

• 社団法人日本薬学会の論文
• 1983-06-25

著者

• 中川 喬

  津村研

• 三橋 博

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 林 紘司

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 三橋 博

  Research Institute For Biology & Chemistry Tsumura & Co.

• 三橋 博

  Tsumura Institute For Biology And Chemistry

• 三橋 博

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 林 紘司

  Tsumura Central Research Laboratories Tsumura & Co.

• 小林 優

  Faculty Of Pharmaceutical Sciencces Hokkaido University

• 林 隆章

  Faculty Of Pharmaceutical Sciences Hokkaido University

• タナベ マサト

  Stanford Research Institute International

• 中川 喬

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 林 紘司

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 林 紘司

  北海道大学薬学部

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