Studies on the Constituents of Asclepiadaceae Plants. XLVII. Acyl Migration of Polyoxypregnane Derivatives

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概要

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• A chemical acyl migration equilibrium between 12β-hydroxyl and 20-hydroxyl groups was found to depend on the C-17 and C-20 configurations in C/D-cis-polyoxypregnane derivatives. In the case of 20S derivatives with a 17α-side chain, the equilibrium mixture was separated to afford 12β-ester compound and 20S-ester compound. On the other hand, separation of the equilibrium mixture of the 20R compound with a 17α-side chain was difficult, since the 20-ester compound changed to an equilibrium mixture at room temperature. In both 20S and 20R compounds having a 17β-side chain, acyl migration was not observed, and the starting material were recovered.

• 社団法人日本薬学会の論文
• 1979-12-25

著者

• 三橋 博

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 坂東 英雄

  Hokkaido Institute of Pharmaceutical Sciences

• 三橋 博

  Research Institute For Biology & Chemistry Tsumura & Co.

• 三橋 博

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 網谷 孝

  Hokkaido Institute Of Pharmaceutical Sciences

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