35 Emericella heterothallicaの産生する新規エピポリチオジオキソピペラジン誘導体およびその関連化合物(口頭発表の部)
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概要
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Emericella heterothallica is a typical heterothallic fungus. From the mycelial extract of E. heterothallica, strain ATCC 16847 (mating type A), novel epidithiodioxopiperazines, emethallicin A (1) as the major metabolite, and emethallicins E (5) and F (6) as the minor components, were isolated along with ergosterol. On the other hand, novel epitetrathiodioxopiperazines, emethallicins B (2) and C (3), and an epitrithiodioxopiperazine, emethallicin D (4), were isolated from the mycelial extract of E. heterothallica, strain ATCC 16824 (mating type a). The structures of 1-6 were determined on the basis of the spectroscopic and chemical investigation of themselves and their derivatives. It is interesting that dibenzyldioxopiperazine derivatives (13-18) were also isolated from the extract of the culture filtrate of the above two strains. Emethallicins A-F (1-6) have the same basic skeleton as apoaranotin (9), aranotin (12), or their related novel basic skeleton. Emethallicins are the first exaples of isolation of mandelic acid, as a free acid and/or its ester, from fungi. Emethallicins A-F (1-6) have the potent inhibitory activity against compound 48/80-induced histamine release from mast cells, and are also 5-lipoxygenase inhibitors.
- 天然有機化合物討論会の論文
- 1989-09-17
著者
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佐藤 俊次
(株)ツムラ生物化学研究所
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川原 信夫
星薬大
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野沢 幸平
星薬大
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仲嶋 正一
星薬大
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河合 賢一
星薬大
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佐藤 俊次
ツムラ生・化研
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陳 政雄
ツムラ生・化研
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Chen Z.
Research Institute for Biology & Chemistry, Tsumura & Company
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三橋 博
ツムラ生・化研
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山崎 幹夫
千葉大薬
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三橋 博
津村研究所
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
Tsumura Institute For Biology And Chemistry
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三橋 博
(株)ツムラ中央研究所
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野沢 幸平
星薬科大学
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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山崎 幹夫
千葉大学
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三橋 博
ツムラ生物・化学研所
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山田 美紀子
Hoshi College of Pharmacy
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Kawai Koji
Basic Research Laboratories Toray Industries Inc.
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陳 政雄
ツムラ研究所
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仲嶋 正一
Faculty Of Pharmaceutical Sciences Hoshi University
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Kawahara N
National Institute Of Health Sciences
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Nakajima S
Shionogi Research Laboratories Shinogi & Co. Ltd.
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