Studies on Spasmolytics. I. Synthesis and Spasmolytic Activities of 4-Acyloxy-1-(1,3-dioxolan-4-ylmethyl) piperidines
スポンサーリンク
概要
- 論文の詳細を見る
Twenty-four derivatives (5) of 4-acyloxy-1-(1,3-dioxolan-4-ylmethyl) piperidine were synthesized and their spasmolytic activities were examined. Some of them showed remarkable papaverine-like and/or atropine-like activities ; in particular, compounds 5c, 5d, 5e, 5l, and 5p were as active or more active than papaverine. The introduction of lipophilic substituents on the dioxolane moiety increased the papaverine-like activity.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
-
長谷川 賀洋
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
-
吉田 誠一郎
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
-
菅井 三郎
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
-
久津間 輝雄
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
-
伊川 博
Research Laboratories, Ohta Pharmaceutical Co., Ltd.
-
赤星 三彌
Research Laboratories, Ohta Pharmaceutical Co., Ltd.,
-
赤星 三彌
Research Laboratories Ohta Pharmaceutical Co. Ltd.
-
長谷川 賀洋
Research Laboratories Ohta Pharmaceutical Co. Ltd.
-
久津間 輝雄
Research Laboratories Ohta Pharmaceutical Co. Ltd.:(present Address) Research Laboratories Fujirebio
-
伊川 博
Central Research Laboratories Fujirebio Inc.
-
吉田 誠一郎
Research Laboratories Ohta Pharmaceutical Co. Ltd.
-
菅井 三郎
Research Laboratories Ohta Pharmaceutical Co. Ltd.
関連論文
- Syntheis and Protective Effect of 1,3,5-Triazine Derivatives, Leukotriene C^4 Antagonist, on HCl・Ethanol-Induced Gastric Lesions in Rats
- 鎮痙薬の研究 (第7報) 4-Benziloyloxy- and 4-(Xanthene-9-carbonyloxy)-1-(1,3-dioxolan-2-ylmethyl)-1-methylpiperidinium塩の薬理作用
- 鎮痙薬の研究 (第6報)1,4-trans-及びcis-4-Benziloyloxy-1-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)-1-methylpiperidinium立体異性体の薬理学的検討
- Structure-Activity Relationship of 3- and 4-Acyloxy-1-(1,3-dioxolan-4-ylmethyl) piperidine Derivatives
- Studies on Topical Antiinflammatory Corticosteroids. III. : Synthesis and Vasoconstrictive Activity of 11β, 17α, 21-Trihydroxy-2'-phenyl-2'H-2,4-pregnadieno[3,2-c]pyrazol-20-one Derivatives
- Studies on Topical Antiinflammatory Corticosteroids. II. : Synthesis and Vasoconstrictive Activity of 11β, 17α, 21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione 17-Methoxy- and (Methylthio)acetates
- Studies on Topical Antiinflammatory Corticosteroids. I. Syntheses and Vasoconstrictive Activities of 11β, 17α, 21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione 17-Ester and 17,21-Diester Derivatives
- 四級アンモニウム型アトロピン誘導体の薬理作用について
- Studies on Spasmolytics. III. Synthesis and Anticholinergic Activity 4-Acyloxy-1-(1,3-dioxolan-2-ylmethyl) piperidines and Their Quaternary Salts
- 鎮痙薬の研究(第4報)N-(2-Acyloxyethyl)-N-(1,3-dioxolan-2-and 4-ylmethyl)-N, N-dimethylammonium誘導体の合成と抗アセチルコリン作用
- Studies on the Reactions of Heterocyclic Compounds. XIV. 1,3-dipolar Cycloaddition of Some Isoquinolinium Ylides with Methyl Propiolate
- A Simple and Efficient Conversion of Aldehyde Acetals into Esters
- A New Efficient Method for Conversion of Corticosteroid 17α, 21-Cyclic Ortho Esters to 17α-Acyloxy-21-chloro-21-deoxy Derivatives
- Polymorphism of Methyl (E)-3-Phenyl-2-propen-1-yl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8411)
- Studies on Spasmolytics. II. Synthesis and Anticholinergic Activities of 4-Acyloxy-1-alkyl-1-(1,3-dioxolan-4-ylmethyl) piperidinium Compounds
- Studies on Spasmolytics. I. Synthesis and Spasmolytic Activities of 4-Acyloxy-1-(1,3-dioxolan-4-ylmethyl) piperidines
- カルコン, フラバノン型化合物の合成研究(第4報) : 2', 4'-ジヒドロキシカルコン, 4'-(ベンチルオキシ)-2'-ヒドロキシカルコン, およびそのピリジンAnalogの紫外線吸収スペクトル
- カルコン, フラバノン型化合物の合成研究(第3報) : 2'-ヒドロキシアザカルコン類の閉環
- カルコン, フラバノン型化合物の合成研究(第2報) : 含窒素カルコン型化合物の合成 その2
- カルコン, フラバノン型化合物の合成研究(第1報) : 含窒素カルコシ型化合物の合成 その1
- 1-置換2-ピペリドン類と塩化ホスホリルとの反応(第4報) : β-ケトアミドと4級塩の相互変換
- 1-置換2-ピペリドン類と塩化ホスホリルとの反応(第3報) : 反応生成物の構造その3 : 4級塩の還元
- 1-置換2-ピペリドン類と塩化ホスホリルとの反応(第2報) : 反応生成物の構造その2 : 4級塩の構造
- 1-置換2-ピペリドン類と塩化ホスホリルとの反応(第1報) : 反応生成物の構造その1 : β-ケトアミド
- Synthesis in the Benzoquinolizine Group. I. Synthesis of 1,2,3,4,6,7-Hexahydro-11bH-benzo[a]quinolizines