Studies on the Reactions of Heterocyclic Compounds. XIV. 1,3-dipolar Cycloaddition of Some Isoquinolinium Ylides with Methyl Propiolate

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概要

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• In the cycloaddition reaction of isoquinolinium bis (methoxycarbonyl) methylide (VI) and isoquinolinium cyano (methoxycarbonyl) methylide (VIII) with methyl propiolate (II), the primary adducts, trimethyl-3,10b-dihydropyrrolo [2,1-α] isoquinoline-1,3,3-tricarboxylate (VII) and dimethyl 3-cyano 3,10b-dihydropyrrolo [2,1-α] isoquinoline-1,3-dicarboxylate (IX), were isolated. The stability of the primary adduct was found to be affected by the kind of substituent at 3-position.

• 社団法人日本薬学会の論文
• 1975-03-25

著者

• 小林 義郎

  Tokyo College of Pharmacy

• 内藤 泰男

  Research Laboratories Ohta Pharmaceutical Co. Ltd.

• 関根 安男

  Research Foundation Itsuu Laboratory

• 熊懐 稜丸

  Tokyo College of Pharmacy

• 内藤 泰男

  Tokyo College of Pharmacy

• 久津間 輝雄

  Tokyo College of Pharmacy

• 久津間 輝雄

  Research Laboratories Ohta Pharmaceutical Co. Ltd.:(present Address) Research Laboratories Fujirebio

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