Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
スポンサーリンク
概要
- 論文の詳細を見る
Replacement of one fluorine atom of the hexafluorocholesterol derivative (4) with a methoxyl group took place during the saponification of the acetyl groups of 4 with methanolic potassium hydroxide to give the pentafluoromethoxy compound (5), which was convetred to the corresponding 1α-hydroxyvitamin D_3 form (6). The pentafluoromethoxy compound (6) was found to be about three times more potent than 1α-hydroxyvitamin D_3 in displacing radio-labeled 1,25-dihydroxy-vitamin D_3 from the chick intestinal receptor, whereas the activity of 6 in response to bone calciummobilization in vitamin D-deficient was rats was slightly lower than that of 1α-hydroxyvitamin D_3.
- 社団法人日本薬学会の論文
- 1988-10-25
著者
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田中 洋子
ベテランズ・アフェアーズ・メディカルセンター
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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池川 信夫
北里大
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田口 武夫
Tokyo College of Pharmacy
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小林 義郎
東京薬科大学薬学部
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池川 信夫
新潟薬大
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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Deluca H
Department Of Biochemistry College Of Agricultural And Life Science University Of Wisconsin
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Deluca H
Univ. Wisconsin‐madison Wi Usa
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崔 洋之
Department Of Chemistry Tokyo Institute Of Technology
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DELUCA HECTOR
Department of Chemistry, Tokyo Institute of Technology
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田中 洋子
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin
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中島 正晴
Tokyo College of Pharmacy
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中沢 正和
Tokyo College of Pharmacy
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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デルカ F.ヘクター
Department Of Biochemistry College Of Agricultural And Life Sciences University Of Wisconsin
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Deluca Hector
Department Of Biochemistry University Of Wisconsin-madison
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