Quantitative Structure-in Vivo Half-Life Relationships of Perfluorochemicals for Use as Oxygen Transporters

概要

論文の詳細を見る
Quantitative structure-activity relationships of a series of perfluorochemicals (PFCs) for use as oxygen transporters were investigated in terms of their in vivo half-lives (t_<1/2>). The logt_<1/2> values can be correlated by a linear combination of lipophilic (e.g., critical solution temperature (CST)), physicochemical (e.g., molecular weight and vapor pressure (P_v)) and topological (e.g., number of fluorines (NOF)) parameters on regression analyses. The most important excretion-rate-determining factor was the CST. The P_v alone of PFCs did not correlate well with logt_<1/2>. However, a combination of CST and P_v produced the most meaningful and important correlation, indicating that P_v plays a pivotal role in the excretion and can be considered a kind of correction factor to the CST. The t_<1/2> can thus be predicted from the combination of CST and P_v. It can also be predicted from structural information : the smaller the NOF, the shorter the t_<1/2>. The incorporation of hetero atom (s) such as nitrogen and oxygen in the PFC molecule, which has been considered to produce better emulsion stability but results in persistence in the body, had relatively little effect in terms of t_<1/2>. These results suggested that, taking the emulsifiability of hetero atom-containing PFCs into consideration, a cyclic F-ether and F-tertiary amine with fused ring (s), containing fewer fluorines than acyclic analogues, might be a good candidate compound as an oxygen transporter.
社団法人日本薬学会の論文
1985-03-25

Quantitative Structure-in Vivo Half-Life Relationships of Perfluorochemicals for Use as Oxygen Transporters

スポンサーリンク

概要

著者

関連論文

スポンサーリンク