Effects of 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) Sulfide on Varioius Ulcer Models in Rats
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概要
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The effects of 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (compd. III-1a) on various experimental ulcers were investigated. The oral administration of compd. III-1a at doses ranging from 30 to 300 mg/kg inhibited the acute gastric ulcerations induced by ethanol, HCl-aspirin and indomethacin in rats. Compound III-1a significantly inhitbited the water immersion stress-induced gastric ulcer at dosee of 3 mg/kg, p.o. The anti-ulcer activity of plaunotolas a referenced drug was equivalent on an ethanol-induced ulcer to that of compd. III-1a, but weaker on HCl・aspirin, indomethacin and stress-induced ulcers than that of compd. III-1a. On indomethacin-produced gastric antral ulcer, compd. III-1a showed the same significant inhibitory activity as spizofurone did at a dose of 100 mg/kg, p.o, Compound III-1a also inhibited hemorrhagic shock-, diethyldithiocarbamic acid (DDC)-and platelet activating factor (PAF)-induced ulcers dose-dependently. Plaunotol only showed significant inhibitory activity on PAF-induced ulcer in these three ulcer models. The consecutive administration of compd. III-1a (100 mg/kg, p.o.) twice a day significantly accelerated the healing of an acetic acid-induced ulcer and that of plaunotol (200 mg/kg, p.o.) showed the same activity. Moreover, orally administered compd. III-1a at a dose of 100 mg/kg decreased the gastric acid secretion in pylorus-ligated rats. The results in the present studysuggest that compd. III-1a has the dual action on ulcer formation.
- 社団法人日本薬学会の論文
- 1991-07-25
著者
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横山 和正
Central Research Laboratory, Green Cross Corporation
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辻川 和丈
阪大薬
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辻川 和丈
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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横山 和正
株式会社ミドリ十字中央研究所
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甲田 伊佐男
Central Reserach Laboratories, The Green Cross Corporation
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永井 仁志
Central Reserach Laboratories, The Green Cross Corporation
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岩井 正和
Central Reserach Laboratories, The Green Cross Corporation
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渡辺 正弘
Central Reserach Laboratories, The Green Cross Corporation
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KOHDA Isao
Japan and Central Research Laboratories, Green Cross Corporation, Ltd.,
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三村 務
大阪大学薬学部
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甲田 伊佐男
Central Research Laboratories The Green Cross Corporation
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岩井 正和
Central Research Laboratories The Green Cross Corporation
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横山 和正
株式会社ミドリ十字 中央研究所
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横山 和正
Central Research Laboratories The Green Cross Corporation
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辻川 和丈
Faculty of Pharmaceutical Sciences, Okayama University
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