Further Studies on the Pharmacological Effect of the Anti-inflammatory Compound, Bis[2-(E-2-octenoylamino)ethyl] Disulfide
スポンサーリンク
概要
- 論文の詳細を見る
Further studies on the pharmacological effect of orally administered bis[2-(E-2-octenoyl-amino)ethyl] disulfide (compd. I-3) was examined by using several experimental models in vivo. Compound I-3 showed analgesic activity, inhibiting both acetic acid- and acetylcholine-induced writhings in mice. This compound also showed antipyretic activity against yeast-induced fever in rats, and significantly inhibited arachidonic acid-induced mortality in mice. However, it had no effect on serotonin-induced paw edema formation or platelet activating factor-acether-induced mortality in mice. The effects of compd. I-3 are suggested to be due to inhibition of prostaglandin biosynthesis.
- 社団法人日本薬学会の論文
- 1989-04-25
著者
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小浜 靖弘
Faculty of Pharmaceutical Sciences, Osaka University
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小濱 靖弘
大阪大学 薬 微薬品化
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辻川 和丈
阪大薬
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辻川 和丈
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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中島 博志
Faculty of Pharmaceutical Sciences, Osaka University
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李 炳〓
Faculty of Pharmaceutical Sciences, Osaka University
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今井 巧
Faculty of Pharmaceutical Sciences, Osaka University
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KOHDA Isao
Japan and Central Research Laboratories, Green Cross Corporation, Ltd.,
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YOKOYAMA Kazumasa
Japan and Central Research Laboratories, Green Cross Corporation, Ltd.,
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Yokoyama Kazumasa
Central Research Laboratories Green Cross Corporation Ltd.
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中島 博志
Faculty Of Pharmaceutical Sciences Osaka University
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三村 務
大阪大学薬学部
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小浜 靖弘
大阪大学薬学部
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甲田 伊佐男
Central Research Laboratories The Green Cross Corporation
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李 炳〓
Faculty Of Pharmaceutical Sciences Osaka University
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Yokoyama K
Showa Pharmaceutical University
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今井 巧
Faculty Of Pharmaceutical Sciences Osaka University
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甲田 伊佐男
Green Cross Corp. Osaka Jpn
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辻川 和丈
Faculty of Pharmaceutical Sciences, Okayama University
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