Biological Properties of Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle
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概要
- 論文の詳細を見る
A novel inhibitor of angiotensin-converting enzyme (ACE) derived from tuna muscle, Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (tuna AI), was chemically synthesized, and its biological properties were investigated. Synthetic tuna AI was found to be chemically and biologically indistinguishable from the native one. Tuna AI inhibited rabbit lung ACE non-competitively with K_i values of 1.7 and 5.7μM with substrates, hippuryl-L-histidyl-L-leucine and angiotensin I, respectively. This peptide (5.3μM) also doubled the effect of bradykinin in the contraction of isolated guinea pig ileum. The peptide did not show zinc chelating activity and carboxypeptidase A inhibitory activity. Thus, tuna AI was found to be a unique ACE inhibitory peptide with non-competitive manner, differing from many naturally occurring peptide ACE-inhibitors.
- 公益社団法人日本薬学会の論文
著者
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OKA Hiroaki
Faculty of Pharmaceutical Sciences, Osaka University
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Yokoyama Kazumasa
Central Research Laboratories Green Cross Corporation Ltd.
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KOHAMA YASUHIRO
Faculty of Pharmaceutical Sciences, Osaka University
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MIMURA TSUTOMU
Faculty of Pharmaceutical Sciences, Osaka University
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Oka H
Faculty Of Pharmaceutical Sciences Osaka University
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Oka Hiroaki
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Faculty Of Pharmaceutical Sciences Osaka University
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Fujita Takuya
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Mimura Tsutomu
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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NAGASE Yasukazu
Life Sciences Affairs, Machida Pharmaceutical Co., Ltd.
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SATAKE Mikio
Central Research Laboratories, Nippon Suisan Co., Ltd.
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NAGASE Yasukazu
Faculty of Pharmaceutical Sciences, Osaka University
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NAKAGAWA Toshito
Faculty of Pharmaceutical Sciences, Osaka University
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MIYAMOTO Takefumi
Faculty of Pharmaceutical Sciences, Osaka University
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MATSUMOTO Shigeru
Faculty of Pharmaceutical Sciences, Osaka University
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SATAKE Mikio
Faculty of Pharmaceutical Sciences, Osaka University
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TAKANE Toshikazu
Faculty of Pharmaceutical Sciences, Osaka University
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FUJITA Takao
Faculty of Pharmaceutical Sciences, Osaka University
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Oka H
Osaka Univ. Osaka
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Kohama Yasuhiro
Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Fujita T
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Satake Mikio
Central Research Laboratories Nippon Suisan Co. Ltd.
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Kayamori Yuzo
Faculty Of Pharmaceutical Sciences Osaka University
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YOKOYAMA Kazumasa
Faculty of Education, Shiga University
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Nakagawa Teruaki
Faculty Of Pharmaceutical Sciences Osaka University:life Science Affairs Mochida Pharmaceutical Co.
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Yokoyama K
Faculty Of Education Shiga University
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Nagase Y
Life Sciences Affairs Machida Pharmaceutical Co. Ltd.
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Miyamoto T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Takane Toshikazu
Faculty Of Pharmaceutical Sciences Osaka University:life Science Affairs Mochida Pharmaceutical Co.
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Matsumoto S
Faculty Of Pharmaceutical Sciences Osaka University:life Science Affairs Mochida Pharmaceutical Co.
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Miyamoto Takefumi
Faculty Of Pharmaceutical Sciences Osaka University
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