POTENT PLATELET ANTIAGGREGANT ACTION OF AN ANTIARRHYTHMIC PEPTIDE (AAP)
スポンサーリンク
概要
- 論文の詳細を見る
A potent platelet antiaggregant action of an antiarrhythmic peptide (AAP) was demonstrated to be a cause of the antithrombotic effect. AAP (10,20 or 40 mg/kg, i. v.) inhibited ex vivo platelet aggregation induced by collagen in a dose-dependent manner. AAP also inhibited the platelet aggregation of platelet-rich plasma (PRP) induced by collagen, Ca-ionophore A-23187,adenosine diphosphate (ADP), thrombin or arachidonic acid in vitro. The IC_<50> was 2.5 mM for collagen 1.7 mM for A-23187,5 mM for ADP, 0.4 mM for thrombin and 0.15 mM for arachidonic acid. The aggregation inhibitory activity of the peptide on washed platelet (WP), in a Ca^<2+>-free medium, was stronger than on PRP. The IC_<50> was 1 mM for collagen and 20 μM for A-23187. No significant difference was found between antiaggregant activities of platelet-free plasma (PFP) from AAP-treated rats and PFP from normal rats supplemented with AAP. The direct action of AAP on platelets was also supported by the incorporation of AAP into platelet cytoplasma which caused a decrease of Ca^<2+>-dependent 3' : 5'-cyclic nucleotide phosphodiesterase (Ca-PDE) activity. It was considered that AAP showed its platelet aggregation inhibitory activity by decreasing intracellular Ca^<2+> concentration through the inhibition of Ca-PDE activity.
- 公益社団法人日本薬学会の論文
著者
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Yokoyama Kazumasa
Central Research Laboratories Green Cross Corporation Ltd.
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KOHAMA YASUHIRO
Faculty of Pharmaceutical Sciences, Osaka University
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MIMURA TSUTOMU
Faculty of Pharmaceutical Sciences, Osaka University
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OKABE MASARU
Faculty of Pharmaceutical Sciences, Osaka University
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岡部 勝
神奈川工科大学応用バイオ科学部応用バイオ科学科
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Okabe M
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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IWABUCHI KAZUHISA
Faculty of Pharmaceutical Sciences, Osaka University
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Kohama Yasuhiro
Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Okabe Masaru
Faculty Of Pharmaceutical Sciences Osaka University
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Kayamori Yuzo
Faculty Of Pharmaceutical Sciences Osaka University
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YOKOYAMA Kazumasa
Faculty of Education, Shiga University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Yokoyama K
Faculty Of Education Shiga University
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Iwabuchi K
Faculty Of Pharmaceutical Sciences Osaka University
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Miyamoto T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Okabe Masaru
Faculty Of Applied Bioscience Department Of Applied Bioscience Kanagawa Institute Of Technology
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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