STUDIES ON HEART. XXI. AMINO ACID SEQUENCE OF ANTIARRHYTHMIC PEPTIDE (AAP) ISOLATED FROM ATRIA
スポンサーリンク
概要
- 論文の詳細を見る
The amino acid sequence of an atrial peptide, AAP, that improves the rhythmicity of cultured myocardial cell clusters, was established as Gly-Pro-4Hyp-Gly-Ala-Gly. This was accomplished by the sequence analyses with dansyl-Edman degradation and carboxypeptidase Y digestion on the isolated native peptide. The hexapeptide and its several constituent peptides were synthesized by using dicyclohexylcarbodiimide as a condensing agent. Synthetic AAP was found to be chemically and biologically indistinguishable from the native one. In a structure-activity correlation of AAP, it was recognized that the whole molecule of this peptide was essential for its antiarrhythmic activity and its promoting effect on spreading phenomenon of myocardial cells in culture.
- 公益社団法人日本薬学会の論文
著者
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KOHAMA YASUHIRO
Faculty of Pharmaceutical Sciences, Osaka University
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AONUMA SHIGERU
Faculty of Pharmaceutical Sciences, Osaka University
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Kohama Yasuhiro
Faculty Of Pharmaceutical Sciences Osaka University
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Aonuma Shigeru
Faculty Of Pharmaceutical Sciences Osaka University
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MAKINO TOSHITAKE
Faculty of Pharmaceutical Sciences, Osaka University
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FUJISAWA YOSHIKO
Faculty of Pharmaceutical Sciences, Osaka University
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Fujisawa Yoshiko
Faculty Of Pharmaceutical Sciences Osaka University
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Makino Toshitake
Faculty Of Pharmaceutical Sciences Osaka University
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Aonuma Shigeru
Faculty of Pharmaceutical Science, Kinki University
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