STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. III. MECHANISM OF ANTIULCEROUS ACTION OF ALKYLATED LIGHT CHAIN (Fr.I-L)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of a new anti-ulcer agent Fr.I-L, a reduced and carboxamidemethylated light chain of human immunoglobulin G, on defensive factors in gastric mucosa were studied. (i) Fr.I-L increased the mucopolysaccharide contents (hexosamine, uronic and sialic acids) in the gastric mucosa of intact rats and inhibited the decrease of mucopolysaccharide contents in the gastric mucosa of rats with phenylbutazone-induced gastric ulcers. (ii) The activation of the biosynthesis of mucopolysaccharides by Fr.I-L was suggested by tracing the incorporation of ^<35>SO^<2->_4 into the gastric mucosa. (iii) The administration of aspirin or phenylbutazone caused an increase of mucopolysaccharase activity in the gastric mucosa and the concomitant administration of Fr.I-L blocked the elevation of the enzyme activities. (iv) Fr.I-L also showed inhibitory activities on the local fibrinolysis and lipid peroxidation in the gastric mucosa.
- 公益社団法人日本薬学会の論文
著者
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MIMURA TSUTOMU
Faculty of Pharmaceutical Sciences, Osaka University
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TSUJIKAWA KAZUTAKE
Faculty of pharmaceutical Sciences, Osaka University
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IWAI MASAKAZU
Central Research Laboratories, Green Cross Corporation, Ltd.
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Tsujikawa K
Osaka Univ. Osaka Jpn
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Itoh M
Faculty Of Pharmaceutical Sciences Osaka University
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Iwai M
Green Cross Corp. Ltd. Osaka
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Mimura T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda K
Faculty Of Pharmaceutical Sciences Osaka University
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AONUMA SHIGERU
Faculty of Pharmaceutical Sciences, Osaka University
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Mimura Tsutomu
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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IWAI MASAKAZU
Faculty of Pharmaceutical Sciences, Osaka University
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MAEDA KAZUHIRO
Faculty of Pharmaceutical Sciences, Osaka University
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KOHDA ISAO
Faculty of Pharmaceutical Sciences, Osaka University
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Tsujikawa Kazutake
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda K
Faculty Of Agriculture Kochi University
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Ikawa Masahito
Genome Information Research Center Osaka University
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Aonuma Shigeru
Faculty Of Pharmaceutical Sciences Osaka University
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Kohda Isao
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Iwai Masakazu
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda Kazuhiro
Faculty of Agriculture, Kochi University
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Aonuma Shigeru
Faculty of Pharmaceutical Science, Kinki University
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