COMPARISON OF DISAPPEARANCE FROM BLOOD AND LYMPHATIC DELIVERY OF HUMAN FIBROBLAST INTERFERON IN RAT BY DIFFERENT ADMINISTRATION ROUTES
スポンサーリンク
概要
- 論文の詳細を見る
Disappearance from the blood and lymphatic delivery of human fibroblast interferon (HuIFN-β) in rats by the various administration routes were studied. Intravenous injection showed a rapid disappearance of HuIFN-β from the blood circulation, however, the clearance rate was greatly decreased after 2 h and the half-lives were 15 min and 2.0 h. Intramuscular, subcutaneous and intraperitoneal injections maintained readily detectable levels in the blood for 12 h, and the half-lives were 2.3,1.7 and 1.2 h, respectively. Lipid-surfactant mixed micelles greatly promoted the absorption of HuIFN-β from the large intestine with extremely high selective lymphatic delivery, whereas intravenous and intramuscular injections showed no selective transfer into the lymphatics.
- 社団法人日本薬学会の論文
著者
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TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Yoshikawa Hiroshi
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Yoshikawa H
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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MURANISHI Shozo
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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SATOH YU-ICHIRO
Basic Research Laboratories, Toray Industries, Inc.
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NARUSE NORIO
Basic Research Laboratories, Toray Industries, Inc.
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Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Satoh Yu-ichiro
Basic Research Laboratories Toray Industries Inc.
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Tatsumi T
Kyoto Univ. Kyoto Jpn
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Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Naruse Norio
Basic Research Laboratories Toray Industries Inc.
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Tatsumi T
Department Of Physics Kyoto University
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yoshikawa Hiroshi
Department of Applied Physics, Handai Frontier Research Center, and Venture Business Laboratory of Center for Advanced Science and Innovation, Osaka University, Suita, Osaka 565-0871, Japan
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