Effects of Diltiazem on Rheological Properties of Human Blood
スポンサーリンク
概要
- 論文の詳細を見る
The in vitro effects of diltiazem (DTZ), a coronary vasodilator, deacetyldiltiazem (D-M1), one of the metabolites of DTZ, and pentoxifylline (PTF) which is known to improve erythrocyte deformation, on the viscosity of platelet poor blood were compared. Furthermore the change in the viscosity of whole blood from patients with effort angina after intravenous administration of DTZ was examined ex vivo. The addition of DTZ into platelet poor blood at 37℃ caused a rapid reduction in blood viscosity and an enhancement of erythrocyte deformability within 5 min, which then diminished in a time-dependent manner. Similar effects were also found by adding D-M1. On the other hand, the effects of PTF appeared after an incubation period of more than 60 min and were enhanced in a timedependent manner. These actions of PTF, but not those of DTZ and D-M1,paralleled the increase of erythrocyte adenosine-triphosphate content. DTZ and D-M1,but not PTF, had biphasic effects on the osmotic behavior of erythrocytes. Whole blood viscosity was reduced significantly during the period 5-30 min after intravenous administration of 10 mg of DTZ, which diminished with the elimination of plasma DTZ. In conclusion, the action mechanisms involved in the effect of DTZ and D-M1 on blood rheological properties appeared to be different from that of PTF. These effects of DTZ are clinically significant in improving the flow properties of blood in vascular diseases.
- 公益社団法人日本薬学会の論文
著者
-
TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
-
MURANISHI Shozo
Department of Biopharmaceutics, Kyoto Pharmaceutical University
-
Ono Takeshi
Hospital Pharmacy Shiga University Of Medical Science
-
Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
-
Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
Sugioka Nobuyuki
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
-
Kawakita Seiichi
First Department Of Internal Medicine Shiga University Of Medical Science
-
Shimakawa H
Shiga Univ. Medical Science
-
Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
-
村西 昌三
京都薬大
-
Morita Kunihiko
Hospital Pharmacy Shiga University Of Medical Science
-
Shibata Nobuhito
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
-
Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University
-
SHIMAKAWA Harumi
Hospital Pharmacy, Shiga University of Medical Science
-
SHIBATA Nobuhito
Hospital Pharmacy, Shiga University of Medical Science
-
Shimakawa Harumi
Hospital Pharmacy Shiga University Of Medical Science
-
Shibata Nobuhito
Hospital Pharmacy Shiga University Of Medical Science
関連論文
- Self-Dissolving Micropile Array Chip as Percutaneous Delivery System of Protein Drug
- Pharmacokinetics of Human Immunodeficiency Virus Protease Inhibitor, Nelfinavir, in Poloxamer 407-Induced Hyperlipidemic Model Rats(Biopharmacy)
- Application of Polyglycolized Glycerides in Protection of Amorphous Form of Etoricoxib during Compression
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. V. MECHANISM OF ANTI-INFLAMMATORY ACTION OF CARBOXAMIDE-METHYLATED L-CHAIN (Fr. I-L) AND H-CHAIN (Fr. I-H) FROM HUMAN SERUM IgG.
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. IV. INDUCTION OF ANTIINFLAMMATORY ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IMMUNOGLOBULIN G AND PHARMACOLOG
- キトサンカプセルを用いた潰瘍性大腸炎治療薬の大腸特異的送達法の開発
- In vitro評価系を用いたペプチド性医薬品の経肺吸収に及ぼす諸要因の検討
- 新規 TRH 類縁体 Azetirelin の消化管吸収改善(2)吸収促進剤を用いた Azetirelin 経口吸収促進製剤の設計
- 新規 TRH 類縁体 Azetirelin の消化管吸収改善(1)Azetirelin 経口投与時の Bioavailability に及ぼす各種要因の検討
- リゾチームの消化管吸収性およびリンパ移行性に及ぼす脂肪酸修飾の影響に関する研究
- In situ single-pass perfusion 法を用いた各種吸収促進剤の有効性と安全性に関する検討
- 吸収助剤の安全性 : 薬物腸管吸収の増大における各種炎症性メディエーターの寄与
- 吸収促進剤の腸管粘膜透過性亢進作用における inflammatory mediator の関与
- アフリカツメガエル摘出肺組織を用いた薬物の肺上皮細胞透過性評価
- 脂肪酸修飾および超音波照射によるペプチドの皮膚透過性の改善
- Synergistic Anti-tumor Effects of Mitomycin C and Bile Salts against L1210 Cells
- Utility of Nano-Sized, Water-in-Oil Emulsion as a Sustained Release Formulation of Glycyrrhizin
- Pharmacokinetics of FK-506,a Novel Immunosuppressant, after Intravenous and Oral Administrations to Rats
- Biological and Pharmaceutical Factors Affecting the Absorption and Lymphatic Delivery of Ciclosporin A from Gastrointestinal Tract
- STUDIES ON THE PROMOTING EFFECT OF LIPID-SURFACTANT MIXED MICELLES (MM) ON INTESTINAL ABSORPTION OF COLLOIDAL PARTICLES. DEPENDENCE ON PARTICLE SIZE AND ADMINISTRATION SITE
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY FUSOGENIC LIPID AS A MEMBRANE MODIFIER
- THE MODE OF ENHANCED ENTERAL ABSORPTION OF MACROMOLECULES BY LIPID-SURFACTANT MIXED MICELLES I
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY FUSOGENIC LIPID-SURFACTANT MIXED MICELLES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS A POORLY ABBSORBABLE DRUG. III.^ HISTOLOGICAL STUDY AFTER ADDITION OF VARIOUS ABSORPTION PROMOTERS IN RATS
- EFFECT OF ADMINISTRATION ROUTE ON THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS POORLY ABSORBABLE DRUGS. II. STUDY ON THE ABSORPTION PROMOTING EFFECT OF AZONE
- ROLE OF THE DISPERSION SYSTEMS CONTAINING FUSOGENIC LIPIDS ON ENHANCED ABSORPTION OF POORLY ABSORBABLE DRUGS FROM THE GASTROINTESTINAL TRACT
- PROMOTION OF THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LIPID-SURFACTANT MIXED MICELLES I. IN VIVO AND TUMORNEUTRALIZING ACTIVITY AGAINST MOUSE ETHRLICH ASCITES TUMOR AND RAT ASCITES HEPATOMA AH66
- COMPARISON OF DISAPPEARANCE FROM BLOOD AND LYMPHATIC DELIVERY OF HUMAN FIBROBLAST INTERFERON IN RAT BY DIFFERENT ADMINISTRATION ROUTES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS POORLY ABSORBABLE DRUGS. I. COMPARISON OF PLASMA LEVELS AFTER ADDITION OF VARIOUS ABSORPTION PROMOTERS IN RAT
- OPTIMAL DOSAGE REGIMEN CALCULATION BASED ON THE REMAINING DRUG CONCENTRATIONS IN PLASMA
- INTESTINAL ABSORPTION OF CARBOXYFLUORESCEIN ENTRAPPED IN LIPOSOMES IN COMPARISON WITH ITS ADMINISTRATION WITH LIPID-SURFACTANT MIXED MICELLES
- A METHOD TO POTENTIATE ENTERAL ABSORPTION OF INTERFERON AND SELECTIVE DELIVERY INTO LYMPHATICS
- MOLECULAR WIGHT DEPENDENCE OF PERMSELECTIVITY TO RAT SMALL INTESTINAL BLOOD-LYMPH BARRIER FOR EXOGENOUS MACROMOLECULES ABSORBED FROM LUMEN
- PHARMACOKINETIC PROPERTY OF HUMAN INTERFERON AFTER ADMINISTRATION BY DIFFERENT ROUTES : PROMOTION OF INTESTINAL ABSORPTION AND SPECIFIC TRANSFER INTO LYMPHATICS
- A-549 細胞系を用いた薬物の肺上皮細胞透過性の評価 - in vivo ラット経肺吸収実験系との相関 -
- アフリカツメガエル肺組織を用いたインスリンの透過性に及ぼす各種添加剤の影響
- キトサンカプセルを用いた生理活性ペプチド及び潰瘍性大腸炎治療薬の大腸特異的送達法の開発
- Evaluation of Insulin Permeability and Effects of Absorption Enhancers on Its Permeability by an in Vitro Pulmonary Epithelial System Using Xenopus Pulmonary Membrane
- Increase of Cytochrome b mRNA by Bis(2-hydroxyethyl) Trisulfide in J774A.1 Cells
- BIOLOGICAL ACTIVITY OF ANTITUMOR SUBSTANCE DERIVED FROM BACILLUS STEAROTHERMOPHILUS
- Potent Synthetic Analogues of Angiotensin-converting Enzyme Inhibitor Derived from Tuna Muscle(Biological Chemistry)
- Enhancement of Heparin-Binding Ability of Fibronectin by S-Carboxamidemethylation
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. VIII. Effect of Carboxamide-Methylated Light Chain (Fr. I-L) on Leukocyte Functions
- STUDIES ON SPERM CAPACITATION USING MONOCLONAL ANTIBODY - DISAPPEARANCE OF AN ANTIGEN FROM THE ANTERIOR PART OF MOUSE SPERM HEAD
- MITOGENIC ACTIVITY AND IN VITRO FERTILIZATION INHIBITORY ACTIVITY OF GENYPTERUS BLACODES LECTIN
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. III. MECHANISM OF ANTIULCEROUS ACTION OF ALKYLATED LIGHT CHAIN (Fr.I-L)
- PURIFICATION AND CHARACTERIZATION OF A FISH LECTIN FROM THE EXTERNAL MUCOUS OF OPHIDIIDAE, GENYPTERUS BLACODES
- Evaluation of Gastrointestinal Transit Characteristics of Oral Patch Preparation Using Caffeine as a Model Drug in Human Volunteers
- Pharmaceutical Approach to HIV Protease Inhibitor Atazanavir for Bioavailability Enhancement Based on Solid Dispersion System(Biopharmacy)
- Electrophysiological Studies on the Mechanism for Enhanced Intestinal Transport of Water-Soluble Compounds by Antibiotic Peptide Bacitracin
- Preparation and Rectal Absorption of Highly Concentrated Glycyrrhizin Solution(Biopharmacy)
- Effectiveness and Toxicity Screening of Various Absorption Enhancers Using Caco-2 Cell Monolayers
- Evaluation of Factors to Decrease Bioavailability of Cyclosporin A in Rats with Gentamicin-Induced Acute Renal Failure (Biopharmacy)
- Effect of Indinavir on the Intestinal Exsorption of Amprenavir, Saquinavir and Nelfinavir after Intravenous Administration in Rats
- Simultaneous determination of glucocorticoids in plasma or urine by high-performance liquid chromatography with precolumn fluorimetric derivatization by 9-anthroyl nitrile
- A Predictive Model for Area Under the Concentration versus Time Curve of Cyclosporin A Using Several Routine Monitoring Results in Renal Transplant Patients
- Evaluation of Factors to Decrease Plasma Concentration of an HIV Protease Inhibitor, Saquinavir in Ethanol-Treated Rats(Biopharmacy)
- Highly sensitive quantification of vancomycin in plasma samples using liquid chromatography-tandem mass spectrometry and oral bioavailability in rats
- Relationship between Excretion Clearance of Rhodamine 123 and P-Glycoprotein (Pgp) Expression Induced by Representative Pgp Inducers(Biopharmacy)
- In Vivo Effects of Cyclosporin A and Ketoconazole on the Pharmacokinetics of Representative Substrates for P-Glycoprotein and Cytochrome P450 (CYP) 3A in Rats(Biopharmacy)
- Effect of Chronic Administration of Ritonavir on Function of Cytochrome P450 3A and P-Glycoprotein in Rats(Biopharmacy)
- Development of an Oral Formulation of Azetirelin, a New Thyrotropin-Releasing Hormone (TRH) Analogue, Using n-Lauryl-β-D-maltopyranoside as an Absorption Enhancer
- IMPROVEMENT OF INTESTINAL ABSORPTION OF PEPTIDES AND PROTEINS BY CHEMICAL MODIFICATION WITH FATTY ACIDS
- CONTRIBUTION OF SH-PROTEINS TO PROMOTIVE TRANSMUCOSAL PERMEATION OF POORLY ABSORBABLE DYE WITH OLEATE IN RAT COLON
- Enhanced Permeability of Phenylalanyl-glycine (Phe-Gly) Across the Intestinal Membranes by Chemical Modification with Various Fatty Acids
- Effects of Various Absorption Enhancers on the Intestinal Absorption of Water Soluble Drugs by in Vitro Ussing Chamber Method : Correlation with an in Situ Absorption Experiment
- Effectiveness and Toxicity Screening of Various Absorption Enhancers in the Large Intestine : Intestinal Absorption of Phenol Red and Protein and Phospholipid Release from the Intestinal Membrane
- Clinical Pharmacokinetics of Mycophenolate Mofetil in Japanese Renal Transplant Recipients : a Retrospective Cohort Study in a Single Center(Biopharmacy)
- Permeation Enhancement of Ascorbic Acid by Self-Dissolving Micropile Array Tip through Rat Skin
- Self-Dissolving Micropiles for the Percutaneous Absorption of Recombinant Human Growth Hormone in Rats(Biopharmacy)
- Long-Term Pharmacokinetic Efficacy and Safety of Low-Dose Ritonavir as a Booster and Atazanavir Pharmaceutical Formulation Based on Solid Dispersion System in Rats(Biopharmacy)
- Antihyperglycemic Effect of Insulin from Self-Dissolving Micropiles in Dogs
- Effect of Water Intake on Pharmacokinetics of Lansoprazole from Fast Disintegrating Tablet in Human Subjects
- Bioadhesive Delivery of Metformin Using Prosopis Gum with Antidiabetic Potential
- Studies on the Intestinal Absorption of Low Molecular Weight Heparin Using Saturated Fatty Acids and Their Derivatives as an Absorption Enhancer in Rats (Pharmacology)
- Bioequivalence study and evaluation study for absorption from oral cavity of lansoprazole fast disintegrating tablet in healthy subjects
- Effect of pH, Dietary Proteins and Trypsin Inhibitors on the Hydrolytic Rate of Human Granulocyte Colony-Stimulating Factor (G-CSF) by Rat Digestive Enzymes
- Absorption of Oligodeoxynucleotide by Suppository from Rat Rectal Route
- Evaluation of Carbamazepine Pharmacokinetic Profiles in Mice with Kainic Acid-Induced Acute Seizures(Miscellaneous)
- Effect of Glycerol-Induced Acute Renal Failure on the Pharmacokinetics of Lidocaine after Transdermal Application in Rats(Biopharmacy)
- Evaluation of Gastrointestinal Mucoadhesive Patch System (GI-MAPS) Containing Caffeine as a Model Drug in Human Volunteers
- COLON DELIVERY SYSTEM FOR PEPTIDE/PROTEIN DRUGS
- Inhibition of Testosterone Biosynthesis in Testicular Microsomes by Various Imidazole Drugs. Comparative Study with Ketoconazole
- A Model to Account for the Blood-to-Plasma Distribution of Cyclosporin A in Human Blood
- Effects of Antimycotics on Hepatic Steroid Metabolism
- Effects of Ozagrel (OKY-046), a Thromboxane Synthase Inhibitor, on Oxidative Drug-Metabolizing Enzymes in Mouse Hepatic Microsomes
- Effects of Diltiazem on Rheological Properties of Human Blood
- Inhibitory Effects of Ketoconazole and Miconazole on Cytochrome P-450-Mediated Oxidative Metabolism of Testosterone and Xenobiotics in Mouse Hepatic Microsomes-Comparative Study with Cimetidine
- A COMPARISON OF THE INHIBITORY EFFECTS OF ROXATIDINE ACETATE HYDROCHLORIDE AND CIMETIDINE ON CYTOCHROME P-450-MEDIATED DRUG-METABOLISM IN MOUSE HEPATIC MICROSOMES AND IN MAN IN VIVO
- Selective Inhibition of Hepatic Microsomal Drug-Metabolism by Mexiletine Hydrochloride
- Retrospective Pharmacokinetic Data Analysis of Cyclosporin A Using Routine Monitoring Data in Renal Transplant Patients : Consideration on Its Pharmacokinetic Profiles and Physiological Factors during Renal Dysfunction
- Improvement of Intestinal Absorption of Biologically Active Peptides by Chemical Modification with Fatty Acids
- ENHANCING MECHANISMS OF INTESTINAL DRUG PERMEATION PRODUCED BY ABSORPTION ENHANCERS
- Rheumatic Fever and Rheumatic Heart Disease in Japan : THE 10th CONFERENCE ON THE 10th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- Design of Drug Delivery Systems Based on Biopharmaceutical Characteristics
- Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries.
- Evaluation of fluorescence polarization immunoassay for determination of cyclosporin in whole blood and its clinical relevance.