Effects of Various Absorption Enhancers on the Intestinal Absorption of Water Soluble Drugs by in Vitro Ussing Chamber Method : Correlation with an in Situ Absorption Experiment

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概要

• 論文の詳細を見る

• The effect of absorption enhancers on the small and large intestinal absorption of drug in rats was examined using an in vitro modified Ussing chamber method, and the results were compared with those from an in situ absorption experiment. Phenol red was chosen as a model drug, while the absorption enhancers used were sodium glycocholate (Na-GC), sodium taurocholate (Na-TC), sodium deoxycholate (Na-DC), EDTA, sodium salicylate (Na-Sal), sodium caprate (Na-Cap), diethyl maleate (DEM) and N-lauryl-β-D-maltopyranoside (LM), all used at a concentration of 20 mM. This modified Ussing chamber method showed that Na-DC and EDTA were the most effective absorption enhancers in the small intestine, whereas Na-DC, EDTA and LM were the most effective absorption enhancers in the large intestine. A good correlation exists between the area under the curve (AUC) (in situ loop model) and the cumulative amount of phenol red absorbed (in vitro medified Ussing chamber method). These results indicated that the in vitro modified Ussing chamber method can be used to evaluate the effects of various absorption enhancers in the intestine.

• 公益社団法人日本薬学会の論文
• 1997-07-15

著者

• YAMAMOTO Akira

  Department of Biopharmaceutics, Kyoto Pharmaceutical University

• MURANISHI Shozo

  Department of Biopharmaceutics, Kyoto Pharmaceutical University

• Quan Ying-shu

  Department Of Biopharmaceutics Kyoto Pharmaceutical University:cosmed Pharmaceutical Co. Ltd.

• KAWABE Yoshiko

  Department of Respiratory Disease, Tokyo National Chest Hospital

• Kawabe Yoshiko

  Department Of Biopharmaceutics Kyoto Pharmaceutical University

• SUGIYAMA Tetsuo

  Department of Chemistry, Faculty of Science, Ehime University

• Sugiyama Tetsuo

  Department Of Biopharmaceutics Kyoto Pharmaceutical University

• 村西 昌三

  京都薬大

• UCHIYAMA Tomomi

  Department of Biopharmaceutics, Kyoto Pharmaceutical University

• Muranishi Shozo

  Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories

• Muranishi Shozo

  Department Of Biopharmaceutics Kyoto Pharmaceutical University

• Uchiyama T

  Shizuoka Inst. Of Sci. And Technol. Shizuoka Jpn

• Yamamoto Akira

  Department Of Biopharmaceutics Kyoto Pharmaceutical University

• Yamamoto Akira

  Department Of Anatomy School Of Medicine University Of Tokushuma

• Yamamoto Akira

  Department Of Anatomy School Of Medicine University Of Tokushima

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