Three-Year Follow-up Results of Angiographic Intervention Trial Using an HMG-CoA Reductase Inhibitor to Evaluate Retardation of Obstructive Multiple Atheroma (ATHEROMA) Study
スポンサーリンク
概要
- 論文の詳細を見る
Background The cardiovascular event rate in Japanese populations is strikingly lower than that in Caucasian populations and it has been postulated that this difference might be because of variations in atherosclerosis progression in patients with coronary artery disease (CAD). However, the rate of angiographically assessed progression and its response to statins has not been well described in Japanese patients. Methods and Results The angiographic intervention trial using an HMG-CoA reductase inhibitor to evaluate the retardation of obstructive multiple atheroma (ATHEROMA) study was a multicenter, randomized, controlled clinical trial investigating the effects of pravastatin on coronary atherosclerosis in Japanese patients with CAD using quantitative coronary angiography. In total, 361 patients with mild to moderate elevated serum total cholesterol concentrations (195-265mg/dl) received diet only (n=179) or diet plus pravastatin 10-20mg/dl (n=182). Over 3 years, low-density lipoprotein-cholesterol in the pravastatin group decreased by 19.5% (p<0.0001). A per-patient analysis showed that minimum lumen diameter increased by 0.034±0.17mm in the pravastatin group, but decreased by 0.006±0.16mm in the diet only group (p=0.04). The mean difference between the treatment groups was 0.040mm (95% confidence interval 0.020, 0.070mm). Conclusion The ATHEROMA study indicates that pravastatin 10-20mg/day for 3 years improves hyperlipidemia, then suppresses progression and induces regression of focal coronary atherosclerosis in Japanese CAD patients with elevated serum cholesterol.
- 社団法人日本循環器学会の論文
- 2005-07-20
著者
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Nobuyoshi Masakiyo
Department of Cardiology, Kokura Memorial Hospital
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Mitsudo Kazuaki
Kurashiki Central Hospital
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Mitsudo Kazuaki
Department Of Cardiology Kurashiki Central Hospital
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Kawato Mitsunori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Mitsudo Kazuaki
Department Of Cardiology Himeji Cardiovascular Center
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Yokoi Hiroyoshi
Department of Cardiology, Kokura Memorial Hospital
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YAMAMOTO Akira
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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Yokoi Hiroyoshi
Department Of Cardiology Kokura Memorial Hospital
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Nobuyoshi Masakiyo
Department Of Cardiology Kokura Memorial Hospital
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Yasumoto Hitoshi
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Mitsudo Kazuaki
Department Of Cardiology
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Mitsudo Kazuaki
Department Of Cardiovascular Medicine Kyoto University
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Kawaguchi Akito
Department Of Etiology And Pathophysiology National Cardiovascular Center Research Institute
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Kawato Mitsunori
Department Of Cardiovascular Medicine Kyoto University
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Mitsudo Kazuaki
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kinugasa Mitsuo
Department Of Cardiovascular Medicine Kyoto University
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Nobuyoshi Masakiyo
Dept. Of Cardiology Kokura Memorial Hosp.
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Yamamoto Akira
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yamamoto Akira
Department Of Anatomy School Of Medicine University Of Tokushuma
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Yamamoto Akira
Department Of Etiology And Pathophysiology National Cardiovascular Center Research Institute
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Yokoi Hiroyoshi
Department Of Cardiac Rehabilitation Kokura Memorial Hospital
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Yamamoto Akira
Department Of Anatomy School Of Medicine University Of Tokushima
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