A METHOD TO POTENTIATE ENTERAL ABSORPTION OF INTERFERON AND SELECTIVE DELIVERY INTO LYMPHATICS
スポンサーリンク
概要
- 論文の詳細を見る
The potentiated absorption of human fibroblast interferon (HuIFN-β) with the aid of lipid-surfactant mixed micelles from the rat large intestine and lymphatic delivery were studied. The administration of HuIFN-β with saline solution alone into the lumen of the large intestine indicated no detectable HuIFN-β in the serum or the lymph for 5 h. Neither lipid (linoleic acid) nor surfactant (HCO60,polyoxyethylene hardened castor oil derivative) could promote the absorption of HuIFN-β. However, the administration with linoleic acid-HCO60 mixed micelles enabled the great absorption of HuIFN-β from the large intestine, and HuIFN-β was delivered into the lymphacics with an extremely high selectivity
- 社団法人日本薬学会の論文
著者
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TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Yoshikawa Hiroshi
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Yoshikawa H
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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MURANISHI Shozo
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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SATOH YU-ICHIRO
Basic Research Laboratories, Toray Industries, Inc.
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NARUSE NORIO
Basic Research Laboratories, Toray Industries, Inc.
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Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Satoh Yu-ichiro
Basic Research Laboratories Toray Industries Inc.
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Tatsumi T
Kyoto Univ. Kyoto Jpn
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Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Naruse Norio
Basic Research Laboratories Toray Industries Inc.
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Tatsumi T
Department Of Physics Kyoto University
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yoshikawa Hiroshi
Department of Applied Physics, Handai Frontier Research Center, and Venture Business Laboratory of Center for Advanced Science and Innovation, Osaka University, Suita, Osaka 565-0871, Japan
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