Self-Dissolving Micropiles for the Percutaneous Absorption of Recombinant Human Growth Hormone in Rats(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The feasibility of self-dissolving micropiles (SDMP) as a percutaneous delivery system of recombinant human growth hormone (rhGH) has been studied in rats using SDMP where dextran was used as a base. After mixing dextran solution with rhGH, SDMPs were prepared by pulling with polypropyrene tips. The mean weight, length and diameter were 0.68±0.05 mg, 3.2±0.5 mm and 0.6±0.2 μm, respectively. To evaluate the bioavailability (BA) of rhGH percutaneously administered by SDMP, an absorption experiment was performed in rats. RhGH SDMPs were inserted into the rats skin, 200 μg kg^<-1>, and plasma rhGH levels were measured by an ELISA method. Peak plasma rhGH level, 132.8±11.8 ng ml^<-1>, appeared at 0.8±0.2h. By comparing the plasma rhGH levels vs. time profiles after the administration of SDMP and intravenous injection of rhGH solution, 5 μg kg^<-1>, BA of rhGH from SDMP was calculated to be 87.5%. Theses results may suggest that SDMP can be used as a novel percutaneous drug delivery system.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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SUGIOKA Nobuyuki
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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ITO Yukako
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Ohashi Yoshinori
Department Of Pharmacokinetics Kyoto Pharmaceutical University
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Sugioka Nobuyuki
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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SHIROYAMA Keiji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Shibata Nobuhito
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Shiroyama Keiji
Department Of Pharmacokinetics Kyoto Pharmaceutical University
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Inoue Yuji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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ITO Yukako
Department of Dermatology and Plastic Surgery, Head & Neck Surgery
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