Enhancement of Heparin-Binding Ability of Fibronectin by S-Carboxamidemethylation
スポンサーリンク
概要
- 論文の詳細を見る
Human plasma fibronectin (FN) was reduced and carboxamidemethylated, and its binding ability to several matrices was analyzed in vitro. The binding of S-carboxamidemethyl (Cam)-FN to heparin-Sepharose was not influenced by either 4M urea, 0.5 M NaCl or 0.5% heparin, but was disrupted by the coexistence of urea and NaCl or heparin. S-Cam-FN, compared with intact FN, obviously had a more potent ability to bind heparin, while it had little or no binding ability to gelatin, fibrin and thrombin-stimulated platelets. A conformational change of S-Cam-FN by heparin-binding has been proposed as a possible mechanism from the result of circular dichroic spectrum measurement.
- 公益社団法人日本薬学会の論文
著者
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OKA Hiroaki
Faculty of Pharmaceutical Sciences, Osaka University
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Yokoyama Kazumasa
Central Research Laboratories Green Cross Corporation Ltd.
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KOHAMA YASUHIRO
Faculty of Pharmaceutical Sciences, Osaka University
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MIMURA TSUTOMU
Faculty of Pharmaceutical Sciences, Osaka University
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OKABE MASARU
Faculty of Pharmaceutical Sciences, Osaka University
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TSUJIKAWA KAZUTAKE
Faculty of pharmaceutical Sciences, Osaka University
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岡部 勝
神奈川工科大学応用バイオ科学部応用バイオ科学科
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Oka H
Faculty Of Pharmaceutical Sciences Osaka University
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Oka Hiroaki
Faculty Of Pharmaceutical Sciences Osaka University
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Okabe M
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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MURAYAMA Norihito
Faculty of Pharmaceutical Sciences, Osaka University
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MIYAMOTO Takefumi
Faculty of Pharmaceutical Sciences, Osaka University
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YAMAMOTO Kohji
Faculty of Pharmaceutical Sciences, Osaka University
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Yamamoto K
Osaka Univ. Osaka Jpn
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Oka H
Osaka Univ. Osaka
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Kohama Yasuhiro
Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Tsujikawa Kazutake
Faculty Of Pharmaceutical Sciences Osaka University
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Okabe Masaru
Faculty Of Pharmaceutical Sciences Osaka University
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kayamori Yuzo
Faculty Of Pharmaceutical Sciences Osaka University
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YOKOYAMA Kazumasa
Faculty of Education, Shiga University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Yokoyama K
Faculty Of Education Shiga University
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Miyamoto T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Murayama Norihito
Faculty Of Pharmaceutical Sciences Osaka University
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Yamamoto Kohji
Faculty Of Pharmaceutical Sciences Osaka University
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Okabe Masaru
Faculty Of Applied Bioscience Department Of Applied Bioscience Kanagawa Institute Of Technology
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Miyamoto Takefumi
Faculty Of Pharmaceutical Sciences Osaka University
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