A New Antiarrhythmic Peptide, N-3-(4-Hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly(Biological)
スポンサーリンク
概要
- 論文の詳細を見る
In order to increase the antiarrhythmic activity of Pro-Hyp-Gly-Ala-Gly (P-5), P-5 analogues with three different hydrophobic substituents, N-3-(4-hydroxyphenyl)propionyl (H), N-3-phenylpropionyl (I) and N-3-phenylpropyl (P), were prepared and their activities were evaluated in CaCl_2-induced arrhythmias in mice. HP-5 showed potent antiarrhythmic activity at 1 mg/kg, i.v. and its potency was much higher than that of P-5 at 10 mg/kg, i.v. IP-5 showed similar potency to P-5, but PP-5 was inactive. Pro-Hyp-Gly-Ala, Pro-Hyp-Gly and Pro-Hyp with the substituent, H, were also ineffective. Thus, 3-(4-hydroxyphenyl)propionylation of the imino nitrogen of Pro in P-5 led to increased potency.
- 社団法人日本薬学会の論文
- 1987-09-25
著者
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Yokoyama Kazumasa
Central Research Laboratories Green Cross Corporation Ltd.
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KOHAMA YASUHIRO
Faculty of Pharmaceutical Sciences, Osaka University
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OKIMOTO NAOTSUGU
Faculty of Pharmaceutical Sciences, Osaka University
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MIMURA TSUTOMU
Faculty of Pharmaceutical Sciences, Osaka University
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FUKAYA CHIKARA
Central REsearch Laboratories, Green Cross Corporation, Ltd.
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WATANABE MASAHIRO
Central REsearch Laboratories, Green Cross Corporation, Ltd.
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Mimura T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura Tsutomu
Faculty Of Pharmaceutical Sciences Osaka University
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Fukaya Chikara
Central Research Laboratories Green Cross Corporation Ltd.
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Mimura Tsutomu
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Kohama Yasuhiro
Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Faculty Of Pharmaceutical Sciences Osaka University
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Kohama Yasuhiro
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Okimoto Naotsugu
Faculty Of Pharmaceutical Sciences Osaka University
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Yokoyama K
Showa Pharmaceutical University
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Kayamori Yuzo
Faculty Of Pharmaceutical Sciences Osaka University
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YOKOYAMA Kazumasa
Faculty of Education, Shiga University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Yokoyama K
Faculty Of Education Shiga University
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Miyamoto T
Faculty Of Pharmaceutical Sciences Osaka University
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Watanabe M
Gifu Univ. Gifu Jpn
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