INHIBITORY EFFECTS OF UNSATURATED FATTY ACIDS OF trans-2-C_<10 : 1> TO trans-2-C_<16 : 1> SEVERAL C_<18 : n> AND C_<20 : n> ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS

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概要

• 論文の詳細を見る

• Among various unsaturated fatty acids which were examined in this experiment, trans-2-tridecenoic acid was found to be a potent inhibitor on gastric secretion in rats (i.p. or i.d.). Therefore, the effects of trans-2-tridecenoic acid on several experimental ulcerations in rats were examined. At the dose of 10 mg/kg, trans-2-tridecenoic acid significantly decreased the ulcer index in pylorus-ligated rats; aspirin-, phenylbutazone-, histamine- and stress-induced ulcerations were also significantly inhibited at the dose of 25 mg/kg. Finally, effects of trans-2-tridecenoic acid on hexosamine and sialic acid contents in the gastric mucous were examined. In intact or phenylbutazone-induced ulcerated rats, trans-2-tridecenoic acid increased the sialic acid levels in the gastric mucous at the dose of 25 mg/kg. The decreased hexosamine content in the gastric mucous by phenylbutazone treatment was recovered by the administration of trans-2-tridecenoic acid.

• 公益社団法人日本薬学会の論文

著者

• MIMURA TSUTOMU

  Faculty of Pharmaceutical Sciences, Osaka University

• IWAI MASAKAZU

  Central Research Laboratories, Green Cross Corporation, Ltd.

• Iwai M

  Green Cross Corp. Ltd. Osaka

• Mimura T

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura Tsutomu

  Faculty Of Pharmaceutical Sciences Osaka University

• Maeda K

  Faculty Of Pharmaceutical Sciences Osaka University

• AONUMA SHIGERU

  Faculty of Pharmaceutical Sciences, Osaka University

• Mimura Tsutomu

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• IWAI MASAKAZU

  Faculty of Pharmaceutical Sciences, Osaka University

• MAEDA KAZUHIRO

  Faculty of Pharmaceutical Sciences, Osaka University

• KOHDA ISAO

  Faculty of Pharmaceutical Sciences, Osaka University

• SASAKI YUKO

  Faculty of Pharmaceutical Sciences, Osaka University

• MOMOSE TAKEFUMI

  Faculty of Pharmaceutical Sciences, Kinki University

• Maeda K

  Faculty Of Agriculture Kochi University

• Ikawa Masahito

  Genome Information Research Center Osaka University

• Aonuma Shigeru

  Faculty Of Pharmaceutical Sciences Osaka University

• Kohda Isao

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Momose Takefumi

  Faculty Of Pharmaceutical Sciences Kinki University

• Sasaki Yuko

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Mimura T

  Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University

• Iwai Masakazu

  Faculty Of Pharmaceutical Sciences Osaka University

• Maeda Kazuhiro

  Faculty of Agriculture, Kochi University

• SASAKI Yuko

  Faculty of Engineering and Resource Science, Akita University

• Aonuma Shigeru

  Faculty of Pharmaceutical Science, Kinki University

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