Increase of Migration of Cultured Endothelial Cells by Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle

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概要

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• The influence of angiotensin-converting enzyme (ACE) inhibitory octapeptide derived from tuna muscle (tuna AI) on the bovine aorta endothelial cell (BAEC) migration was investigated, as compared with captopril. BAEC migration was quantitated 6 d after release from contact inhibition by a teflon fence assay. The culture grown in the presence of tuna AI (1 and 10 μM) clearly exhibited an increase in migration, compared with the control. The media collected from tuna AI (1 and 10 μM)-stimulated BAECs significantly exhibited the interleukin (IL) -1 activity that was detected by the thymocyte costimulation assay with phytohemagglutinin. Although tuna AI was a weaker ACE inhibitor than captopril, the increasing effect of tuna AI on the migration and the IL-1 generation in BAECs was slightly greater than that of captopril. In quiescent BAECs, tuna AI (1 μM) apparently induced c-myc and platelet derived growth factor (PDGF) A-chain messenger ribonucleic acid (mRNA) expressions within 30 min, which persisted for 6 h. In contrast, captopril induced a very low expression of c-myc mRNA, and had no relation to PDGF A-chain mRNA expression. These results suggest that the increase of BAEC migration by tuna AI, unlike captopril, is likely related to the induction or activation of IL-1,and c-myc and PDGF mRNAs, in addition to the inhibition of the conversion of endogenous angiotensin I to angiotensin II.

• 公益社団法人日本薬学会の論文

著者

• OKA Hiroaki

  Faculty of Pharmaceutical Sciences, Osaka University

• Yokoyama Kazumasa

  Central Research Laboratories Green Cross Corporation Ltd.

• KOHAMA YASUHIRO

  Faculty of Pharmaceutical Sciences, Osaka University

• MIMURA TSUTOMU

  Faculty of Pharmaceutical Sciences, Osaka University

• Oka H

  Faculty Of Pharmaceutical Sciences Osaka University

• Oka Hiroaki

  Faculty Of Pharmaceutical Sciences Osaka University

• Itoh M

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura Tsutomu

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura Tsutomu

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• IIDA Kentaro

  Faculty of Pharmaceutical Sciences, Osaka University

• MURAYAMA Norihito

  Faculty of Pharmaceutical Sciences, Osaka University

• ITOH Masahiko

  Faculty of Pharmaceutical Sciences, Osaka University

• ITOH Masaaki

  Faculty of Pharmaceutical Sciences, Osaka University

• YING Xing

  Faculty of Pharmaceutical Sciences, Osaka University

• Oka H

  Osaka Univ. Osaka

• Kohama Yasuhiro

  Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University

• Kohama Yasuhiro

  Faculty Of Pharmaceutical Sciences Osaka University

• Kohama Yasuhiro

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Ying X

  Osaka Univ. Osaka Jpn

• Ying Xing

  Faculty Of Pharmaceutical Sciences Osaka University

• Iida K

  Faculty Of Pharmaceutical Sciences Osaka University

• Kayamori Yuzo

  Faculty Of Pharmaceutical Sciences Osaka University

• YOKOYAMA Kazumasa

  Faculty of Education, Shiga University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Yokoyama K

  Faculty Of Education Shiga University

• Iida Kentaro

  Faculty Of Pharmaceutical Sciences Osaka University

• Miyamoto T

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Murayama Norihito

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

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