Production of Angiotensin-Converting Enzyme Inhibitors from Baker's Yeast Glyceraldehyde-3-phosphate Dehydrogenase

スポンサーリンク

概要

• 論文の詳細を見る

• Angiotensin-converting enzyme (ACE) inhibitors were excised from the molecule of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) preparation of baker's yeast by heating at 120℃ in 1 M AcOH-20 mM HCl. Three inhibitors were then purified by gel-permeation and reversephase chromatographies. One of the yeast ACE inhibitors, YG-3,was GAPDH peptide 79-89 (Pro-Ala-Asn-Leu-Pro-Trp-Gly-Ser-Ser-Asn-Val, IC_<50> : 18 μM), and contained the sequence homologous to vertebratc ACE inhibitors (GAPDH peptides 79-86 or 81-88). Other inhibitors, YG-1 (Gly-His-Lys-Ile-Ala-Thr-Phe-Gln-Glu-Arg, IC_<50> : 0.4 μM) and YG-2 (Gly-Lys-Lys-Ile-Ala-Thr-Tyr-Gln-Glu-Arg, IC_<50> : 2 μM), corresponded to amino acid residues 68-77 in two different forms of yeast GAPDH, respectively. Their sequences were quite different from those of the venom peptide family. YG-1 was the most potent ACE inhibitor among yeast and vertebrate GAPDH peptides excised by acid-limited proteolysis. Thus, yeast GAPDH seems to be an excellent source of naturally occurring ACE inhibitors.

• 公益社団法人日本薬学会の論文

著者

• OKA Hiroaki

  Faculty of Pharmaceutical Sciences, Osaka University

• Yokoyama Kazumasa

  Central Research Laboratories Green Cross Corporation Ltd.

• KOHAMA YASUHIRO

  Faculty of Pharmaceutical Sciences, Osaka University

• MIMURA TSUTOMU

  Faculty of Pharmaceutical Sciences, Osaka University

• Inamori Yoshihiko

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Oka H

  Faculty Of Pharmaceutical Sciences Osaka University

• Oka Hiroaki

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura Tsutomu

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura Tsutomu

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• MURAYAMA Norihito

  Faculty of Pharmaceutical Sciences, Osaka University

• TERAMOTO Tetsuyuki

  Faculty of Pharmaceutical Sciences, Osaka University

• NAGASE Yasukazu

  Life Sciences Affairs, Machida Pharmaceutical Co., Ltd.

• NAGASE Yasukazu

  Faculty of Pharmaceutical Sciences, Osaka University

• NAKAGAWA Toshito

  Faculty of Pharmaceutical Sciences, Osaka University

• TSUJIBO Hiroshi

  Faculty of Pharmaceutical Sciences, Osaka University

• INAMORI Yoshihiko

  Faculty of Pharmaceutical Sciences, Osaka University

• Oka H

  Osaka Univ. Osaka

• Kohama Yasuhiro

  Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University

• Kohama Yasuhiro

  Faculty Of Pharmaceutical Sciences Osaka University

• Kohama Yasuhiro

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Kayamori Yuzo

  Faculty Of Pharmaceutical Sciences Osaka University

• YOKOYAMA Kazumasa

  Faculty of Education, Shiga University

• Nakagawa Teruaki

  Faculty Of Pharmaceutical Sciences Osaka University:life Science Affairs Mochida Pharmaceutical Co.

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Yokoyama K

  Faculty Of Education Shiga University

• Nagase Y

  Life Sciences Affairs Machida Pharmaceutical Co. Ltd.

• Miyamoto T

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Murayama Norihito

  Faculty Of Pharmaceutical Sciences Osaka University

• Teramoto Tetsuyuki

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Tsujibo Hiroshi

  Faculty Of Pharmaceutical Sciences Osaka University

関連論文

• Preparation of Biologically Active and Site Specifically Radioiodinated Recombinant Human Insulin-like Growth Factor-I
• Further Studies on the Pharmacological Effect of the Anti-inflammatory Compound, Bis[2-(E-2-octenoylamino)ethyl] Disulfide
• A New Antiarrhythmic Peptide, N-3-(4-Hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly(Biological)
• STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. V. MECHANISM OF ANTI-INFLAMMATORY ACTION OF CARBOXAMIDE-METHYLATED L-CHAIN (Fr. I-L) AND H-CHAIN (Fr. I-H) FROM HUMAN SERUM IgG.
• STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. IV. INDUCTION OF ANTIINFLAMMATORY ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IMMUNOGLOBULIN G AND PHARMACOLOG
• STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. IV. INDUCTION OF ANTIINFLAMMATORY ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IMMUNOGLOBULIN G AND PHARMACOLOG
• Molecular Cloning of the Gene Encoding a Novel β-N-Acetylhexosaminidase from a Marine Bacterium, Alteromonas sp. Strain O-7, and Characterization of the Cloned Enzyme(Biochemistry & Molecular Biology)
• Molecular Cloning of the Gene Encoding an Outer-Membrane-Associated β-N-Acetylglucosaminidase Involved in Chitin Degradation System of Alteromonas sp. Strain O-7
• Pharmacokinetics of Two Rectal Dosage Forms of Ketoprofen in Patients after Anal Surgery
• Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells
• Isolation of immunosuppressive phospholipids from marine bacteria
• Increase of Cytochrome b mRNA by Bis(2-hydroxyethyl) Trisulfide in J774A.1 Cells
• Increase of Migration of Cultured Endothelial Cells by Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle
• BIOLOGICAL ACTIVITY OF ANTITUMOR SUBSTANCE DERIVED FROM BACILLUS STEAROTHERMOPHILUS
• Potent Synthetic Analogues of Angiotensin-converting Enzyme Inhibitor Derived from Tuna Muscle(Biological Chemistry)
• Production of Angiotensin-Converting Enzyme Inhibitors from Baker's Yeast Glyceraldehyde-3-phosphate Dehydrogenase
• Isolation and Identification of Hydroquinone in Baker's Yeast(Biological Chemistry)
• Bacillus stearothermophilus Glyceraldehyde-3-phosphate Dehydrogenase as a Source of Angiotensin-converting Enzyme Inhibitors(Biological Chemistry)
• Enhancement of Heparin-Binding Ability of Fibronectin by S-Carboxamidemethylation
• Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. VIII. Effect of Carboxamide-Methylated Light Chain (Fr. I-L) on Leukocyte Functions
• RESPONSE OF IMMUNOREACTIVE ANTIARRHYTHMIC PEPTIDE (IR-AAP) LEVEL ASSOCIATED WITH EXPERIMENTAL ARRHYTHMIA IN RATS
• POTENT PLATELET ANTIAGGREGANT ACTION OF AN ANTIARRHYTHMIC PEPTIDE (AAP)
• STUDIES ON SPERM CAPACITATION USING MONOCLONAL ANTIBODY - DISAPPEARANCE OF AN ANTIGEN FROM THE ANTERIOR PART OF MOUSE SPERM HEAD
• MITOGENIC ACTIVITY AND IN VITRO FERTILIZATION INHIBITORY ACTIVITY OF GENYPTERUS BLACODES LECTIN
• STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. III. MECHANISM OF ANTIULCEROUS ACTION OF ALKYLATED LIGHT CHAIN (Fr.I-L)
• PURIFICATION AND CHARACTERIZATION OF A FISH LECTIN FROM THE EXTERNAL MUCOUS OF OPHIDIIDAE, GENYPTERUS BLACODES
• INHIBITORY EFFECTS OF UNSATURATED FATTY ACIDS OF trans-2-C_ TO trans-2-C_ SEVERAL C_ AND C_ ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS
• HOMOLOGY OF AN ACROSOME-REACTED SPERM-SPECIFIC ANTIGEN TO CD46
• ANGIOTENSIN-CONVERTING ENZYME INHIBITOR CUT OUT OF YEAST GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
• Biological Properties of Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle
• DETERMINATION OF IMMUNOREACTIVE ANTIARRHYTHMIC PEPTIDE (AAP) IN RATS
• Cloning and Nucleotide Sequence of the Gene Encoding a Serine Proteinase Inhibitor Named Marinostatin from a Marine Bacterium, Alteromonas sp. Strain B-10-31
• The Mechanism of the Bactericidal Activity of Hinokitiol
• The Excellence of Aomori Hiba (Hinokiasunaro) in Its Use as Building Materials of Buddhist Temples and Shinto Shrines
• Biological Activity of β-Dolabrin, γ-Thujaplicin, and 4-Acetyltropolone, Hinokitiol-Related Compounds(Biochemistry/Molecular Biology)
• Molecular Characterization of an Intracellular β-N-Acetylglucosaminidase Involved in the Chitin Degradation System of Streptomyces thermoviolaceus OPC-520
• Biological Activity of α-Thujaplicin, the Isomer of Hinokitiol(Biochemistry/Molecular Biology)
• A Thermostable Laccase from Streptomyces lavendulae REN-7 : Purification, Characterization, Nucleotide Sequence, and Expression(Biochemistry & Molecular Biology)
• Biological Activity of Tropolone(Biochemistry/Molecular Biology)
• Biological Activity of 4-Acetyltropolone, the Minor Component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAK.
• Cloning and Expression of an α-L-Arabinofuranosidase Gene (stxIV) from Streptomyces thermoviolaceus OPC-520, and Characterization of the Enzyme(Biochemistry & Molecular Biology)
• Isolation and Characterization of the Genes Encoding Two Metalloproteases (MprI and MprII) from a Marine Bacterium, Alteromonas sp. Strain O-7(Biochemistry & Molecular Biology)
• Cloning, Sequencing, and Expression of the Gene Encoding an Intracellular β-D-Xylosidase from Streptomyces thermoviolaceus OPC-520(Biochemistry & Molecular Biology)
• Biological Activity of α-Thujaplicin, the Minor Component of Thujopsis dolabrata SIEB.et ZUCC.var.hondai MAKINO
• Cytotoxicity of the Hinokitiol-Related Compounds, γ-Thujaplicin and β-Dolabrin
• Family 19 Chitinases from Streptomyces thermoviolaceus OPC-520 : Molecular Cloning and Characterization
• Antifungal Activity of Hinokitiol-Related Compounds on Wood-Rotting Fungi and Their Insecticidal Activities
• Phytogrowth-Inhibitory Activities of β-Dolabrin and γ-Thujaplicin, Hinokitiol-Related Compounds and Constituents of Thujopsis dolabrata Sieb. et Zucc. var hondai MAKINO
• Biological Activity of Alkyl 2-(Acylthio)benzoates
• Purification and Characterization of a Thermostable Chitinase from Streptomyces thermoviolaceus OPC-520 and Cloning of the Encoding Gene
• A Facile Method for the Stereoselective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones
• New Six- to Eight-Membered-Ring Formation Based on the Intramolecular Endo- Mode Ring Closure of Allenyl (Substituted Phenyl)alkyl Ketones
• Inhibitory Activity of Podophyllotoxin and Matairesinol-derivative Lignans on the Root Growth of Brassica campestris
• THE MECHANISMS OF DELAYED INSECTICIDAL ACTION OF STREPTOTHRICIN ANTIBIOTICS
• Dioxopyrrolines.LXII. Diels-Alder Reaction of 1-Aryl-4-and 5-methoxycarbonyl-1H-pyrrole-2,3-diones with Various 1,3-Dienes
• Stereoselective Synthesis of Tetrasubstituted (Z)-Alkenes from Aryl Alkyl Ketones Utilizing the Horner-Wadsworth-Emmons Reaction
• Biological Activity of Purpurogallin
• Phylogenetic Relationship of Psychoactive Fungi Based on the rRNA Gene for a Large Subunit and Their Identification Using the TaqMan Assay
• Antimicrobial Activity and Metalloprotease Inhibition of Hinokitiol-Related Compounds, the Constituents of Thujopsis dolabrata S. and Z. hondai MAK.
• Inhibitory Activities of Rhodanine Derivatives on Plant Growth
• Synthesis of Methyl and Ethyl 3-Alkylthiazolidine-4(R)-carboxylates and Their Roots Inhibition of the Growth of Brassica campestris
• Root-growth Inhibition by DL-Homocysteine Thiolactone and Its Related Compounds
• EFFECTS OF BRANCHED CHAIN FATTY ACIDS OF Iso-C_ TO Iso-C_ ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS
• STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. II. INHIBITORY EFFECTS OF CARBOXAMIDEMETHYLATED L CHAIN FROM HUMAN SERUM IgG ON VARIOUS ULCER MODELS AND ITS INHIBITION MECHANISM
• STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. I. INDUCTION OF ANTI-ULCEROGENIC ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IgG AND PROPERTIES OF ACTIVE SUBFRAGMENTS
• Identification of the Positions of Disulfide Bonds of Chitinase from a Marine Bacterium,Alteromonas sp. Strain O-7
• INCREASE OF ANTI-ULCEROGENIC ACTIVITY BY REDUCTION AND ALKYLATION OF DISULFIDE BONDS OF A GLOBULIN FRACTION FROM BOVINE SERUM
• PHYSIOLOGICAL ACTIVITY OF STREPTOTHRICIN ANTIBIOTIC AND STRUCTURE-ACTIVITY RELATIONSHIP
• STUDIES ON ASPIRIN DERIVATIVES WITH VERY LITTLE SIDE EFFECT. IV.^ INHIBITORY EFFECT OF ASPIRIN-ISOPROPYLANTIPYRINE (AIA) ON SEVERAL EXPERIMENTAL THROMBOSES
• STUDIES ON ASPIRIN DERIVATIVES WITH VERY LITTLE SIDE EFFECTS. III. ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM OF TRITIUM-LABELED ASPIRIN-ISOPROPYLANTIPYRINE (AIA) IN RATS
• STUDIES ON HEART. XXI. AMINO ACID SEQUENCE OF ANTIARRHYTHMIC PEPTIDE (AAP) ISOLATED FROM ATRIA
• STUDIES ON ASPIRIN DERIVATIVES WITH VERY LITTLE SIDE EFFECT. II. POTENT PLATELET ANTI-AGGREGANT ACTIVITY AND NO MUTAGENECITY OF ASPIRIN-ISOPROPYLANTIPYRINE (AIA)
• PC54 MICROBIAL TRANSFORMATION OF ANTITUMOR SUBSTANCE, DEOXYPODOPHYLLOTOXIN
• Inhibitory Activities of 3-Thiophenecarboxylic Acid and Related Compounds on Plant Growth
• Cloning and Sequence Analysis of a Protease-encoding Gene from the Marine Bacterium Alteromonas sp. Strain O-7
• Purification and Characterization of β-N-Acetylglucosaminidase from Alteromonas sp.Strain O-7
• Intravascular Behavior of a Perfluorochemical Emulsion
• A New Amino Acid, (2S,3R)-(-)-3-Hydroxybaikiain from Russula subnigricans HONGO(Organic,Chemical)
• EFFECT OF NORMAL C_-C_ FATTY ACIDS AND THEIR RELATED COMPOUNDS ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS
• Retention of Perfluorochemicals in Tumor-Bearing Rats
• INHIBITORY EFFECTS OF ALKYLATED BENCE-JONES PROTEIN, k-TYPE LIGHT CHAIN, FROM URINE OF A PATIENT WITH MACROGLOBULINEMIA ON GASTRIC JUICE SECRETION AND ULCERATION IN RATS
• Electronic interactions in triple exciplex of the 1,4-dicyanobenzene and naphthalene system.
• Fluorescence Polarization of Intramolecular EDA Complexes in (9,10-Dicyanoanthracene)-(CH2)n-(Naphthalene)
• The Electronic Structure of the Electron-donor-acceptor System in the Excited State. The Exciplex and the Fluorescent State of EDA Complex

もっと見る 閉じる

スポンサーリンク