Biological Activity of α-Thujaplicin, the Minor Component of Thujopsis dolabrata SIEB.et ZUCC.var.hondai MAKINO

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概要

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• α-Thujaplicin, a minor component of Thujopsis dolabrata SIEB.et Zucc.var.hondai MAKINO, which was synthesized, showed the antibacterial activity, phytogrowth-inhibitory effect, inhibition of carboxypeptidase A and cytotoxic effect. Antibacterial activity of α-thujaplicin on Enterococcus faecalis IFO-12965 [minimum inhibitory concentration(MIC) : 1.56μg/ml] was higher than that of genetamicin (MIC : 6.25μg/ml)used as a positive control. Inhibitory activity of α-thujaplicin on carboxypeptidase A [50% inhibitory concertration(IC_<50>): 3.24×10^<-5>M] was higher than that of 1, 10-phenanthroline used as a positive control. α-Thujaplicin showed germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno even at the low concentration of 10 ppm and its growth inhibitory effect was stronger than that of sodium 2, 4-dichlorophenoxyacetate used as a standard. α-Thujaplicin at 1.25μg/ml inhibited cell growth of human stomach cancer KATO-III by 86%, and Ehrlich's ascites carcinoma by 87%, respectively. This compound even at the low concentration of 0.32μg/ml also inhibited cell growth of the former by 66%, and the latter by 75%, respectively. The acute toxicity of α-thujaplicin [50% lethal dose(LD_<50>)value : 256mg/kg]in mice was as strong as those of β-dolabrin(LD_<50> value : 232mg/kg)and γ-thujaplicin(LD_<50> value : 277mg/kg).

• 公益社団法人日本薬学会の論文
• 2001-06-01

著者

• Matsumura E

  Osaka University Of Pharmaceutical Sciences

• Matsumura Eiko

  Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• IN Yasuko

  Osaka University of Pharmaceutical Sciences

• In Y

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• Morita Y

  Osaka Organic Chemical Industry Ltd.

• TSUJIBO Hiroshi

  Osaka University of Pharmaceutical Sciences

• INAMORI Yoshihiko

  Osaka University of Pharmaceutical Sciences

• Okabe Toshihiro

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• SAKAGAMI YOSHIKAZU

  Osaka Prefectural Institute of Public Health

• Morita Yasuhiro

  Osaka Organic Chemical Industry Ltd

• SAKAGAMI YOSHIKAZU

  Kinki University, Faculty of Agriculture

• YASUDA Masahide

  Osaka University of Pharmaceutical Sciences

• OKABE TOSHIHIRO

  Aomori Industrial Research Center

• OHE TATSUHIKO

  Osaka Manicipal Research Institute

• ISHIDA NAKAO

  The Sendai Institute of Microbiology

• TSUJIBO Hiroshi

  Department of Microbiology, Osaka University of Pharmaceutical Sciences

• OKABE Toshihiro

  Japan Industrial Research Institute of Aomori Prefecture

• Sakagami Yoshikazu

  Kinki University Faculty Of Agriculture

• Sakagami Y

  Osaka Prefectural Institute Of Public Health

• Okabe T

  Aomori Industrial Research Center

• Ishida N

  The Sendai Institute Of Microbiology

• Okabe Toshihiro

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Miki Y

  Kinki Univ. Higashi‐osaka Jpn

• Yoshimura M

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Yasuda Masahide

  Osaka College Of Pharmacy

• Tsujibo H

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Osaka College Of Pharmacy

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