Biological Activities of 3,3'-Dihydroxy-α,β-diethylstilbene and Its Isomer, Diethylstilbestrol(Biological)

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概要

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• 3,3'-Dihydroxy-a,β-diethylstilbene (I) and its isomer, diethylstilbestrol (II), showed antifungal activity against plant-pathogenic fungi, phytogrowth-inhibitory activity and ahypotensive effect on rats. First, I exhibited rather strong antifungal activity against plant-pathogenic fungi; the minimal inhibitory concentrations against Fusarium oxysporum f. sp. lyxopersici. Botryotinia fuckeliana and Pyrenophora graminea were 4μg/ml. On the other hand, the activity of II was weaker than that of I. Secondly, both compounds inhibited the growth of roots of two plants species even at low concentration of 50ppm. Thirdly, I and II showed a hypotensive effect on rats (I, -23.33±5.03mmHg; II, -41.00±2.40mmHg; 1Omg/kg, i.v.). Unlike II, I has virtually no hormonal activity. It is noteworthy that in spite of the loss of hormonal character in going from II to I, the abovementioned activities are fully retained.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• Morita Y

  Osaka Organic Chemical Industry Ltd.

• TSUJIBO Hiroshi

  Osaka University of Pharmaceutical Sciences

• INAMORI Yoshihiko

  Osaka University of Pharmaceutical Sciences

• MIKI Yasuyoshi

  Faculty of Pharmaceutical Sciences, Kinki University

• KUBO MAYURI

  Osaka College of Pharmacy

• Ogawa M

  Osaka Univ. Pharmaceutical Sciences Matsubara‐shi Jpn

• Miki Y

  Kinki Univ. Higashi‐osaka Jpn

• OGAWA MASAFUMI

  Osaka University of Pharmaceutical Sciences

• TAKEMURA SHOJI

  Faculty of Pharmaceutical Sciences, Kinki University

• Takemura S

  Kinki Univ. Osaka Jpn

• Takemura Shoji

  Faculty Of Pharmaceutical Sciences Kinki University

• Inamori Yoshihiko

  Osaka College Of Pharmacy

• Miki Yasuyoshi

  Faculty Of Pharmaceutical Sciences Kinki University

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