GEOMETRY OF MUSCARINIC AGONISTS
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概要
- 論文の詳細を見る
In order to account for a common geometric character of the skeleton of known muscarinic agonist molecules in the drug-receptor interaction, common key atoms, terminal methyl carbon, two oxygen, and ammonium nitrogen atoms were remarked which were shown by computer calculation to be concentrated at definite points in space and to be arranged nearly in a plane. Comparison of overlapped patterns of potent agonists and weak-acting or inactive analogues drew a conclusion that the complemental receptor site have a relatively flat shape.
- 公益社団法人日本薬学会の論文
著者
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TAKEMURA SHOJI
Faculty of Pharmaceutical Sciences, Kinki University
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Takemura Shoji
Faculty Of Pharmaceutical Sciences Kinki University
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- GEOMETRY OF MUSCARINIC AGONISTS