Cytotoxicity of the Hinokitiol-Related Compounds, γ-Thujaplicin and β-Dolabrin

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概要

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• γ-Thujaplicin and β-dolabrin, the contsituents of the wood of Thujopsis dolabrata S_<IEB>.et Zucc.var.hondai showed strong in vitro cytotoxic effects against the human stomach cancer cell lines KATO-III and Ehrich's ascites carcinoma. The cytotoxic effects of the two compounds against both tumor cell lines were clear when cell growth was measured by the 3-(4, 5-dimethylthiazol-2-yl)2, 5-diphenyltetrazoium bromide(MTT)method. γ-Thufaplicin and β-dolabrin at 0.32μg/ml inhibited cell growth of human stomach cancer KATO-III by 85 and 67%, and Ehrllich's ascites carcinoma by 91 and 75%, respectively. There is no large difference in cytotoxicity between these compounds, but the activity of γ-thujaplicin was slightly more potent than that of β-dolabrin. On the other hand, hinokitiol accetate did not show a cyutotoxic effect, suggesting that at least a part of the mechanism of the cytotoxic effect of hinokitiol-related compounds is due to metal chelation between the carbonyl group at C-1 and the hydroxyl group at C-2 in the tropolone skeleton of these moleculars. The acute toxicities[50% lethal dose (LD_<50>)value : intraperitoneal injection, Van der Waedam]of γ-thujaplicin and β-dolabrin in mice were 277mg/kg and 232mg/kg, respectively.

• 公益社団法人日本薬学会の論文
• 2001-03-01

著者

• Matsumura E

  Osaka University Of Pharmaceutical Sciences

• Matsumura Eiko

  Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• IN Yasuko

  Osaka University of Pharmaceutical Sciences

• In Y

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• Morita Y

  Osaka Organic Chemical Industry Ltd.

• TSUJIBO Hiroshi

  Osaka University of Pharmaceutical Sciences

• INAMORI Yoshihiko

  Osaka University of Pharmaceutical Sciences

• Okabe Toshihiro

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• OKABE Toshihiro

  Industrial Research Institute of Aomori Prefecture

• Morita Yasuhiro

  Osaka Organic Chemical Industry Ltd

• YASUDA Masahide

  Osaka University of Pharmaceutical Sciences

• OKABE TOSHIHIRO

  Aomori Industrial Research Center

• OHE TATSUHIKO

  Osaka Manicipal Research Institute

• ISHIDA NAKAO

  The Sendai Institute of Microbiology

• ISHIDA Nakao

  Sendai Institute of Microbiology

• TSUJIBO Hiroshi

  Department of Microbiology, Osaka University of Pharmaceutical Sciences

• DATE Tomomi

  Osaka university of Pharmaceutical Sciences

• Okabe T

  Aomori Industrial Research Center

• Ishida N

  The Sendai Institute Of Microbiology

• Okabe Toshihiro

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Miki Y

  Kinki Univ. Higashi‐osaka Jpn

• Yoshimura M

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Yasuda Masahide

  Osaka College Of Pharmacy

• Tsujibo H

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Osaka College Of Pharmacy

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