Antifungal Activity of Hinokitiol-Related Compounds on Wood-Rotting Fungi and Their Insecticidal Activities

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概要

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• Hinokitiol (β-thujaplicin), β-dolabrin and γ-thujaplicin isolated from Thujopsis dolabrata SIEB, et ZUCC. var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their mininum inhibitory concentration (MIC) values being 0.2 μg/ml. Their antifungal activities on D. dickinsii IFO-4979 were as high as that of amphotericin B used as a positive control. Three compounds had strong insecticidal activities on Tyrophagus putrescentiae [50%-lethal concentration (LC_<50> : g/m^2) 0.25 in hinokitiol, 0.02 in β-dolabrin and γ-thujaplicin]. Their insecticidal activities were higher than that of N, N-diethyl-m-toluamide (DEET, LC_<50> : 1.46 g/m^2) used as a positive control. Three compopunds also showed strong insecticidal activity on Coptotermes formosanus [LC_<50> (g/m^2) 0.07 in hinokitiol, 0.05 in β-dolabrin and γ-thujaplicin], although their insecticidal activities were much lower than that of commerical chloropyrifos (LC_<50> : 0.00016 g/m^2).

• 公益社団法人日本薬学会の論文
• 2000-08-01

著者

• Inamori Yoshihiko

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Shibata M

  Fumakilla Ltd.

• Morita Y

  Osaka Organic Chemical Industry Ltd.

• TSUJIBO Hiroshi

  Osaka University of Pharmaceutical Sciences

• INAMORI Yoshihiko

  Osaka University of Pharmaceutical Sciences

• Okabe Toshihiro

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• SAKAGAMI YOSHIKAZU

  Osaka Prefectural Institute of Public Health

• OKABE Toshihiro

  Industrial Research Institute of Aomori Prefecture

• Morita Yasuhiro

  Osaka Organic Chemical Industry Ltd

• SAKAGAMI YOSHIKAZU

  Kinki University, Faculty of Agriculture

• OKABE TOSHIHIRO

  Aomori Industrial Research Center

• OHE TATSUHIKO

  Osaka Manicipal Research Institute

• ISHIDA NAKAO

  The Sendai Institute of Microbiology

• TSUJIBO Hiroshi

  Department of Microbiology, Osaka University of Pharmaceutical Sciences

• SUGIURA Masaaki

  Fumakilla Ltd.

• KUMEDA Yuko

  Osaka Prefectural Institute of Public Health

• SHIBATA Mistunobu

  Fumakilla Ltd.,

• Sakagami Yoshikazu

  Kinki University Faculty Of Agriculture

• Sakagami Y

  Osaka Prefectural Institute Of Public Health

• Okabe T

  Aomori Industrial Research Center

• Ishida N

  The Sendai Institute Of Microbiology

• Okabe Toshihiro

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Miki Y

  Kinki Univ. Higashi‐osaka Jpn

• Tsujibo H

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Osaka College Of Pharmacy

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