Five New Nortropane Alkaloids and Six New Amino Acids from the Fruit of Morus alba LINNE Growing in Turkey

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概要

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• Investigation of the constituents of the fruits of Morus alba LINNE(Moraceae)afforded five new nortropane alkaloids(1-5)along with nor-ψ-tropine(6)and six new amino acids, morusimic acids A-F(7-12). The structures of the new compounds were determined to be 2α, 3β-dihydroxynortropane(1), 2β, 3β-dihydroxy-nortropane(2), 2α, 3β, 6exo-trihydroxynortropane(3), 2α, 3β, 4α-trihydroxynortropane(4), 3β, 6exo-dihydroxy-nortropane(5), (3R)-3-hydroxy-12-{(1S, 4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yl}-dodecanoic acid-3-O-β-D-glucopyranoside(7), (3R)-3-hydroxy-12-{(1S, 4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yl}-dodecanoic acid(8), (3R)-3-hydroxy-12-[(1R, 4R, 5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid-3-O-β-D-glucopyranoside(9), (3R)-3-hydroxy-12-[(1R, 4R, 5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid(10), (3R)-3-hydroxy-12-[(1R, 4R, 5S)-4-hydroxy-5-hydroxymethyl-piperidin-1-yl]-dodecanoic acid-3-O-β-D-glucopyranoside(11), and (3R)-3-hydroxy-12-[(1R, 4S, 5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid(12)on the basis of spectral and chemical data.

• 公益社団法人日本薬学会の論文
• 2002-02-01

著者

• SHIBANO Makio

  Osaka University of Pharmaceutical Sciences

• KUSANO Genjiro

  Osaka University of Pharmaceutical Sciences

• Shibano M

  Laboratory Of Pharmacognostical Sciences Osaka University Of Pharmaceutical Sciences

• Shibata M

  Fumakilla Ltd.

• TSUKAMOTO Daisuke

  Osaka University of Pharmaceutical Sciences

• COSKUN Maksut

  Ankara University, Faculty of Pharmacy

• ERDURAK Ceyda

  Ankara University, Faculty of Pharmacy

• Shibano M

  Osaka University Of Pharmaceutical Sciences

• ORIHARA Shiho

  Osaka University of Pharmaceutical Science

• Kusano G

  Osaka University Of Pharmaceutical Sciences

• Coskun Maksut

  Department Of Pharmaceutical Botany Faculty Of Pharmacy Ankara University

• Erdurak Ceyda

  Faculty Of Pharmacy Ankara University

• Kusano Genjiro

  Osaka University Of Phamaceutical Sciences

• ORIHARA Shiho

  Astronomical Institute, Osaka Kyoiku University

• Orihara Shiho

  Osaka University Of Pharmaceutical Sciences

• Orihara S

  Osaka Kyoiku Univ. Osaka

• KUSANO Genjirou

  Osaka University of Pharmaceutical Sciences

• GUNENC Aysegul

  Ankara University, Faculty of Pharmacy

• Gunenc Aysegul

  Ankara University Faculty Of Pharmacy

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