Characterization of a Glycyrrhizin-Deficient Strain of Glycyrrhiza uralensis
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概要
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A triterpene saponin, glucoglycyrrhizin, was isolated from a glycyrrhizin-deficient strain 83-555 of Glycyrrhiza uralensis (Leguminosae), and the structure was determined by chemical and spectral data to be 3-O-[β-<span style="font-variant: small-caps;">D</span>-glucopyranosyl-(1→2)-β-<span style="font-variant: small-caps;">D</span>-glucuronopyranosyl]-glycyrrhetinic acid. Since this saponin has a 2′-O-β-<span style="font-variant: small-caps;">D</span>-glucopyranosyl moiety instead of the 2′-O-β-<span style="font-variant: small-caps;">D</span>-glucuronopyranosyl moiety of glycyrrhizin, the glucuronidation of 3-O-β-<span style="font-variant: small-caps;">D</span>-glucuronopyranosyl-glycyrrhetinic acid leading to glycyrrhizin is inhibited in this strain. All 4 offspring of the 83-555 strain produced glucoglycyrrhizin. Interestingly, 2 of the offspring produced both glycyrrhizin and glucoglycyrrhizin, and sequence analysis of the pkr gene suggested that these 2 offspring were hybrids of 83-555 strain and glycyrrhizin-producing strains.
- 公益社団法人 日本薬学会の論文
著者
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IINUMA Munekazu
Gifu Pharmaceutical University
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SHIBANO Makio
Osaka University of Pharmaceutical Sciences
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Ozaki Kazuo
Kyoto Herbal Garden Takeda Pharmaceutical Co. Ltd.
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Hayashi Hiroaki
School Of Pharmacy Iwate Medical University
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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Watanabe Hitoshi
Kyoto Herbal Garden Takeda Pharmaceutical Co. Ltd.
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Watanabe Hitoshi
Kyoto Herbal Garden, Takeda Pharmaceutical Co., Ltd.
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Fujii Isao
School of Pharmacy, Iwate Medical University
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